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This book addresses methodological techniques for researching cognitive impairment, Alzheimer's disease, the biophysics and structure of the nervous system, the physiology of memory, and the analysis of EEG data. Intended for researchers in cognitive, be
This volume will first review existing cholinesterase inhibitors prescribed for Alzheimer’s disease (AD) patients followed by some target mechanisms with ongoing clinical trials. It offers a glimpse of what our future medicine cabinets may look like for AD patients. This volume is part of a series that covers hot topics of frontier research summarized by reputed scientists in the field.
There is a wide scope of clinical phenomenology in Alzheimers disease, regarding the age of onset, presenting features, rate of progression and appearance of other clinical manifestation. Although clinical appearance and neuropathological hallmarks have been defining AD since its first description, major factors which trigger pathology are still unknown. The role of comorbidity is discussed controversially. Important environmental risk factors in AD development are continuous stress, low education and cardiovascular risk factors such as alcohol intake, smoking, hypertension. The role of lipids and cholesterol has been recognized, but the relevant pathogenetic steps are still to be identified. There is an urgent need to understand molecular disease pathogenesis in order to develop early therapeutic targets for the disease.
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Roughly one of every three Americans has some form of cardiovascular disease (CVD), including more than 70% of persons older than 75 years of age. Long associated with increased risk for mortality and disability, CVD is also a major risk factor for stroke and cerebrovascular disease. There has been growing consensus that CVD is also an important contributor to poor neurocognitive outcome in own right. Numerous studies now link CVD to accelerated cognitive decline, and structural and functional brain abnormalities, including neurodegnerative conditions in the elderly. While vascular dementia is the most obvious example of severe brain dysfunction directly tied to chronic vascular disease, evi...
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Focusing on theoretical, policy and practice issues which are predicted to become fundamental priorities in the near future, the contributors to this important book examine how dementia care works around the globe. They explore the theory underpinning dementia care, the applications of this theory in the latest dementia care research and how this research is influencing and shaping practice. The contributors are leading practitioners, policy influencers and researchers who analyse case studies from the UK, the USA, Canada, Australia, India, France and Malta with the aim of encouraging a dialogue and exchange of interdisciplinary initiatives and ideas. Their insights into how policy and dementia strategies are developed, and the range of approaches that can be taken in dementia care practice, are a positive step towards ensuring that the needs of people with dementia around the world are met, both now and in the future. This book makes essential reading for practitioners, researchers, policy makers and students in the field of dementia care.