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Handbook of Membrane Channels
This handbook provides a thorough account of recent directions in membrane channel research. Each subject is covered in terms of channel biophysics, pharmacology, and molecular biology. The introductory chapter reviews methodologies of molecular biology currently used for studying molecular structure and function of membrane channels and specific domains in channel proteins.
Drug Discovery and Evaluation: Safety and Pharmacokinetic Assays
Many aspects of drug safety have become an outstanding and even persistent issue and may occur during the process of both drug discovery and development. Until 15 years ago, drug discovery and evaluation was primarily a sequential process starting with the selection of the most pharmacologically active compound from a series of newly synthesized small molecule chemical series by means of distinctive pharmacological assays. Safety aspects were addressed by evaluation of the selected compound at high doses in a series of specific studies directed at indications other than the intended indication of the new compound. These tests are then followed by pharmacokinetic studies, which are primarily ...
Purine Metabolism in Man—II
The study of gouty arthritis has provided a common meeting ground for the research interests of both the basic scientist and the clinician. The interest of the chemist in gout began 1776 with the isolation of uric acid from a concretion of the urinary tract by the Swedish chemist SCHEELE. The same substance was subsequently extracted from a gouty tophus by the British chemist WOLLASTONE in 1797 and a half century later the cause of the deposits of sodium urate In such tophi was traced to a hyperuricemia in the serum of gouty patients by the British physician Alfred Baring GARROD who had also received training in the chemical laboratory and was therefore a fore-runner of many of today's clini...
Drug Discovery and Evaluation
This reference book contains a comprehensive selection of the most frequently used assays for reliably detecting pharmacological effects of potential drugs, including tests for cardiovascular, analgesic, psychotropic, metabolic, endocrine, respiratory, renal, and immunomodulatory activities. Each of the over 700 assays comprises a detailed protocol with the purpose and rationale of the method, a description of the experimental procedure, a critical assessment of the results and their pharmacological and clinical relevance, and pertinent references. Identification of specific tests is facilitated by the enclosed CD-ROM which allows for a quick and full text research. An appendix with guidelines and legal regulations for animal experiments in various countries will help to plan these experiments properly in accordance with the welfare of laboratory animals.
Comprehensive Human Physiology
Comprehensive Human Physiology is a significantly important publication on physiology, presenting state-of-the-art knowledge about both the molecular mechanisms and the integrative regulation of body functions. This is the first time that such a broad range of perspectives on physiology have been combined to provide a unified overview of the field. This groundbreaking two-volume set reveals human physiology to be a highly dynamic science rooted in the ever-continuing process of learning more about life. Each chapter contains a wealth of original data, clear illustrations, and extensive references, making this a valuable and easy-to-use reference. This is the quintessential reference work in the fields of physiology and pathophysiology, essential reading for researchers, lecturers and advanced students.
Drug Discovery and Evaluation: Pharmacological Assays
Now expanded and updated to include molecular biology and genetic engineering techniques. The second edition of this successful reference book contains a comprehensive selection of the most frequently used assays for reliably detecting the pharmacological effects of potential drugs. Each of the more than 1000 assays comprises a detailed protocol outlining the purpose and rationale of the method, a critical assessment of the results and their pharmacological and clinical relevance. The enclosed and fully searchable CD ROM allows easy identification of specific tests. An appendix with up-to-date guidelines and legal regulations for animal experiments in various countries will help the reader to plan experiments more effectively.
Aromatic Plants
The use of aromatic plants has been practised since ancient times as is evidenced by records of Chinese, Egyptian, Mesopotamian, Greek and Roman origin; recent findings in Pakistan prove that it goes as far back as 5000 years. Accordingly, the importance and value ascribed to them were always high. Either as a medicine, a foodstuff, a seasoning, a cosmetic or an element of religious rituals the aromatic plant was indispensable. It is not to be forgotten that desire tor the riches of India - spices among which - and the struggle to monopolize the trade of the latter con tributed to the opening of new sea routes, discovering of continents and altering the picture of the known world. With the advent of modern civilization, characterized by scientific and technological development which dIverted estimation and consumption towards artificial products, aromatic plants experienced a temporary de cline of use retaining, however, theIr importance In sectors such as the culinary art and cosmetics industry.
