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Circadian Rhythms and Their Impact on Aging
Biological rhythms time the ebb and flow of virtually every physiological process, and their mutual coordination guarantees the integrity of the organism over space and time. Aging leads to the disintegration of this coordination, as well as to changes in the amplitude and/or frequency of the underlying rhythms. The results of this are accelerated loss of health during aging, and in experimental model systems curtailed lifespan occurs. This book will examine the machinery that constitutes circadian systems and how they impact physiologic processes. It will also discuss how disturbances of circadian rhythms can lead to complex diseases associated with aging. Much of this treatment will focus on metabolism and genome stability. Importantly, the chapters in this book will encompass work in several different models, in addition to human. The book will conclude with a discussion of modeling approaches to biologic cycles and chronotherapy, for future research and translation.
Reproductive Endocrinology and Biology
We have now reached the mid-point of our editorial task of putting together the compendium, Principles of Medical Biology, which is supposed to be composed of twenty-five modules. The present single-volume module on reproductive endocrinology and biology is in more than one respect a continuation of Module 10 (in two volumes) dealing with molecular and cellular endocrinology. In addition, it intersects, as it should, with various parts of obstetrics and gynaecology, both of which are abetted by technology. One has only to recall that the practical benefits of ultrasound in perinatal medicine and in vitro fertilisation are the outcome of the technological revolution in biomedicine. Whether we...
Reproduction: Part B
Vertebrate Endocrinology: Fundamentals and Biomedical Implication, Volume 4, Part B: Reproduction provides information relevant to the structure and function of the vertebrate reproductive endocrinology. This book deals with a variety of subjects, including oocyte maturation, gestation, ovulation, vitellogenesis, spermatogenesis, as well as the maturation and aging of the reproductive system. Organized into nine chapters, this volume starts with an overview of the gonadotropin-releasing hormone (GnRH), which is the physiological regulator of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) release from the pituitary gland. This book then explores the significance of gonadotropins in animal life, which act directly on the gonads of vertebrates and control the development, maturation, and release of gametes. Other chapters consider the interactions between the reproductive system and the pineal gland in photoperiodic mammals. The final chapter deals with the evolution of the endocrine systems, which is involved in the control of vertebrate reproduction. Reproductive endocrinologists and developmental neuroendocrinologists will find this book extremely useful.
Sleep and Clocks in Aging and Longevity
This edited volume focuses on the interplay between sleep and circadian rhythms with health, aging and longevity. Sleep is absolutely important for human health and survival, as insufficient sleep is associated with a plethora of conditions, including the poor quality of life, onset of several diseases, and premature death. The sleep–wake cycle is an evolutionary conserved neurobiological phenomenon, and is a prominent manifestation of the biological clocks localised in the suprachiasmatic nucleus (SCN). Understanding bidirectional relationship between sleep and circadian rhythms is of utmost importance and urgency, especially in the context of modern lifestyle where sleep is often out of ...
Melatonin: Role in Plant Signaling, Growth and Stress Tolerance
The new edited volume on phytomelatonin and its diverse roles in plants under a challenging environment shall be an important reference book with updated information and future perspectives on the involvement of this biomolecule in stress resilience in plants. Investigations on different aspects of melatonin in plants have undergone a prolific surge in the last decade. In view of such a considerable volume of investigations in melatonin, the proposed new volume will collate its role in different aspects of plants signaling, growth and metabolism. In this context, it has been important to understand its function as a stress priming molecule that executes associative synergistic relation with ...
Neurochemistry
Compiles 195 contributions from the June 1996 meeting. Part I (clinical aspects and pathology) discusses the role of neuroprotection and neurorescue in ischemia, stroke, and neuronal injury, as well as neurochemical mechanisms, mood disorders, and the significance of cerebrospinal fluid examinations for diagnosis and treatment. Part II (cellular functions) covers nutrient transport, energy metabolism, and metabolic trafficking in brain cells, and the role of neurotrophic molecules. Part III (molecules/methods) describes functional aspects of neuroactive compounds, with a special focus upon acetylocholine, taurine, amino acid neurotransmitters, and neuropeptides. Also discusses the role of lipid mediators, brain proteins, and new insights in methodology. Annotation copyrighted by Book News, Inc., Portland, OR
Fish Research
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The Aging Clock
The pineal is regarded as an ontogenic and evolutionary point of departure for research on the causes of senescence, suppported by in vivo experimental evidence, such as pineal cross-transplantation. Among the findings reported here, that reinforce the concept of the central clock, is the unique ability of melatonin to keep dangerous hydroxyl radicals under control. In addition, studies on the effect of caloric restriction and nutritional factors are building blocks in the understanding of how and why we age and develop cancer, together with other studies such as: the role of ubiquitous zinc and of extra-pineal melatonin; the disruption of biological rhythms; ultra-structure in brain diseases and dementia; the transacting factors as key regulatory proteins that mediate families of stress response genes; the aging antigen; the mother steroid DHEA during aging; the role of protein kinase C; the loss of D2 dopamine receptors during aging; brain amyloid formation; the role of cell cycles and cyclic AMP; the pineal peptides; and the decay of central neuro-endocrine-immune functions during aging.
Tryptophan, Serotonin, and Melatonin
This volume contains the proceedings of the Ninth Meeting of the "International Study Group for Tryptophan Research" (lSTRY), held at the University of Hamburg, Germany, from October 10 to 14, 1998. At this meeting the recent developments in the field of tryptophan research were presented by leading researchers from all over the world in 81 oral and 48 poster contri butions. Research on tryptophan and its derivatives provides an inexhaustible subject. At the conference we tried to compose a multifacetted picture of the recent investiga tions through contributions from the major disciplines involved. Thus, we tried to strike a balance between basic research topics and clinical, nutritional or...
