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Effects of Complement Opsonization of HIV on Dendritic Cells
Dendritic cells are key players during HIV pathogenesis, and shape both the immediate immune response at the site of infection as well as directing the adaptive immune response against the virus. HIV has developed a plethora of immune evasion mechanisms that hijack dendritic cell functions, suppressing their ability to mount an accurate immune response and exploiting them for efficient viral transfer to target T cells. To achieve successful replication within dendritic cells without triggering danger signaling, HIV accomplishes a delicate balance where only a low level of transcription can be sustained without triggering antiviral responses that would harm the virus. Here, we describe how th...
Lymph Node T Cell Dynamics and Novel Strategies for HIV Cure
Currently, more than 36 million people are infected with HIV. Although the introduction of highly active anti-retroviral therapy (HAART) has led to substantial advances in the clinical management of HIV infected individuals, HAART cannot completely eliminate the virus. This is because CD4 T helper cells, harboring the virus, remain dormant reservoirs. These reservoirs are difficult to measure and are present even in HAART-treated HIV infected individuals with undetectable levels of HIV in the blood. A growing body of studies has revealed follicular helper (Tfh) CD4 T cells, a highly differentiated CD4 T cell population localized in immunologically sanctuary sites (follicle/germinal center), ...
Corpus-Based Research Into Language
For over two decades Jan Aarts has been actively involved in corpus linguistic research. He was the instigator of a large number of projects, and he was responsible for what has become known as the Nijmegen approach to corpus linguistics. It is thanks to him that words like TOSCA and LDB have become household names in the corpus linguistic community. The present volume has been collected in his honour. The contributions in it cover a wide range of topics in the field of corpus linguistic research, especially those in which Jan Aarts takes a keen interest: corpus encoding and tagging, parsing and databases, and the linguistic exploration of corpus data. The contributions in this volume discuss work done in this field outside Nijmegen, for the obvious reason that we do not wish to present him with a report on work in which he is himself involved.
Geographic Information Systems: Concepts, Methodologies, Tools, and Applications
Developments in technologies have evolved in a much wider use of technology throughout science, government, and business; resulting in the expansion of geographic information systems. GIS is the academic study and practice of presenting geographical data through a system designed to capture, store, analyze, and manage geographic information. Geographic Information Systems: Concepts, Methodologies, Tools, and Applications is a collection of knowledge on the latest advancements and research of geographic information systems. This book aims to be useful for academics and practitioners involved in geographical data.
Systemic Functional Insights on Language and Linguistics
This book features a collection of 10 interviews with Christian M.I.M. Matthiessen, who is a key figure in Systemic Functional Linguistics (SFL) and has collaborated closely with M.A.K. Halliday since the 1980s. As noted by Professor Chang Chenguang, Editor of the M.A.K. Halliday Library Functional Linguistics Series, “this collection of interviews serves as an important reference for scholars and students of SFL. It provides a unique perspective on the theoretical development and future outlooks of SFL, as well as Matthiessen’s own interpretations of the theory. It also enriches our understanding of SFL and is a very useful addition to the series.” Written in an engaging dialogic format, the book paints a vivid picture of SFL thriving among the landscape of general linguistics and of SFL as an important tool now being applied in various areas.
Independent Schools Yearbook 2012-2013
The highly-respected book of reference of sought-after Independent Schools in membership of the Independent Schools Council's Associations: HMC, GSA, The Society of Heads, IAPS, ISA and COBIS.
Global Tuberculosis Control
WHO's twelfth annual report on global tuberculosis control in a series that started in 1997.
