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Somatic Cell Nuclear Transfer
This book provides the reader with a unique developmental, molecular and cell biological view of the exciting SCNT technology, while also discussing its pitfalls and possible future directions and detours. The cellular events arising from SCNT procedure, such as the need for nuclear remodeling, disposal of donor cell organelles, presence of foreign mitochondrial DNA and altered mode of oocyte activation are explained.
Molecular and Cellular Mechanisms in Reproduction and Early Development
The Research Topic aims to support progress towards understanding the different sets of developmental processes that are absolutely required to complete all the steps essential for successful embryonic development, under physiological conditions. We sought contributions that dealt with single cells, interaction between cells as well as intra- and extracellular signal transduction. The Research Topic presents original studies covering experimental and theoretical approaches, descriptions of new methodologies, reviews and opinions.
Knobil and Neill's Physiology of Reproduction
The Fourth Edition of Knobil & Neill continues to serve as a reference aid for research, to provide the historical context to current research, and most importantly as an aid for graduate teaching on a broad range of topics in human and comparative reproduction. In the decade since the publication of the last edition, the study of reproductive physiology has undergone monumental changes. Chief among these advances are in the areas of stem cell development, signaling pathways, the role of inflammation in the regulatory processes in the various tissues, and the integration of new animal models which have led to a greater understanding of human disease. The new edition synthesizes all of this n...
Principles of Cloning
Principles of Cloning, Second Edition is the fully revised edition of the authoritative book on the science of cloning. The book presents the basic biological mechanisms of how cloning works and progresses to discuss current and potential applications in basic biology, agriculture, biotechnology, and medicine. Beginning with the history and theory behind cloning, the book goes on to examine methods of micromanipulation, nuclear transfer, genetic modification, and pregnancy and neonatal care of cloned animals. The cloning of various species—including mice, sheep, cattle, and non-mammals—is considered as well. The Editors have been involved in a number of breakthroughs using cloning techni...
Advances in Enzyme Regulation
This volume contains papers of 23 outstanding scientists who are working at the leading edge of metabolic regulation studies. Much of the volume focuses on novel aspects of signal transduction with emphasis on the role of phospholipase C in cell control mechanisms. One of the highlights of this volume is always the Special Symposium Lecture. This lecture was given for fifteen years by Nobel laureate, Sir Hans A. Krebs (UK) (now deceased). This year the Lecture was given by Nadir Maraldi, Director of the Laboratory of Cellular Biology and Electron Microscopy, University of Bologna, Italy. Professor Maraldi's presentation is on the important and novel subject of "Nuclear Proteins and Human Disease."
Regulation of Intracellular Ca2-release Channels by Ca2+ and Ca2+-binding Proteins
This is a Ph.D. dissertation. Almost everything we do is controlled by Ca2+, how we move, how our hearts beat and how our brains process information and store memories. Ca2+ is indeed a ubiquitous second messenger involved in a diversity of cellular activities such as muscular contraction, neurotransmitter release, synaptic plasticity, gene transcription, cell proliferation and apoptosis. The average cytosolic concentration of Ca2+ in resting cells ranges from 50nM to 100nM, reaching values close to 1uM when the cell is stimulated by a variety of physiological stimuli, while in the extracellular milieu this concentration is about 1mM. This large concentration gradient allows intracellular Ca2+ to work as a useful second messenger. Contents include: General Introduction, Objectives, Results, General Discussion, Summary.
