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Biological Therapy for Inflammatory Bowel Disease
The treatment of inflammatory bowel disease (IBD) has posed a major challenge since its appearance. Biomedical researchers, physicians, gastroenterologists, and surgeons have struggled to improve the quality of life of their patients and have sought, above all else, to keep the disease under remission for as long as possible. Blockers for tumoral necrosis factor alpha (TNF-alpha) were the first biological drugs to be discovered and for this reason they played a crucial role in the subsequent evolution of IBD treatment. The aim of this book is to provide an overview of such drugs and the latest developments in IBD immunopathology. Our contributors discuss the main indications, efficacy, and possible side effects of the different types of drugs available today for IBD treatment.
Natural Plant Products in Inflammatory Bowel Diseases
Natural Plant Products in Inflammatory Bowel Diseases: Preventive and Therapeutic Potential organizes all evidence to understand which natural products are the first steps of investigation and which have strong evidence of their effects in inflammatory bowel diseases, have been tested in clinical trials, and have received approval to be officially used. In addition to providing information regarding the research with natural products in inflammatory bowel diseases, this reference will also highlight the molecular mechanisms behind the effects of natural products in inflammatory bowel diseases with the aid of figures, video animations and dynamic tables. Compiled from research group members f...
Identification of Biomarkers, New Treatments, and Vaccines for COVID-19
The novel coronavirus 2019 (COVID-19) has caused a serious global pandemic in just one year. Nearly every country and territory in the world has been affected by the virus. The virulence and infection rate of the virus are profound, and has required extreme social distancing measures across the globe in order to prevent overwhelming the healthcare services and hospitals. COVID-19 appears to have the greatest effects on elderly individuals and those who have co-morbid diseases, such as diabetes and obesity. As the cases and death rate remain high, there are justified fears of this virus remaining for several months or years to come. To address this, a rapid and unprecedented worldwide mobiliz...
Adipose Tissue
Adipose tissue is a specialized connective tissue which, depending on type, plays different and significant roles in the human body: protects against environmental factors, stores lipids and triacylglycerol, synthesizes fatty acids and is involved in the process of thermogenesis. It is also a major secretory organ and highly active metabolic tissue. It secretes, for example, cholesterol, retinol, steroid hormones, prostaglandins and proteins known as "adipokines". Some of these molecules may be associated with pathologies such as obesity and insulin resistance. In humans, there are two main sites of adipose tissue accumulation: visceral and subcutaneous. Obesity is a worldwide health problem. This book also discusses a series of up-to-date topics about this pathology.
The Stem Cell Microenvironment and its Role in Regenerative Medicine and Cancer Pathogenesis
How stem cells behave is very much a factor of their local microenvironment, also known as the stem cell niche. Physical, chemical, or electrical signals from the neighboring cells or biochemical signals from distant cells are crucial in the cell fate decision process. A major challenge of tissue engineering is to mimic the natural cell environment by designing very sophisticated scaffolds able not only to mechanically support cells, but also to release signals biologically relevant for governing stem cell fate. In addition, increasing evidence suggests that abnormal interaction of stem cells with their niche is responsible for altered cell function leading to malignant transformation. This ...
Inflammatory Bowel Disease
Inflammatory Bowel Disease, 2nd edition presents updated information about inflammatory bowel disease in health-care workers. The theoretical content is based on controlled and randomized clinical studies in the meta-analyzes, conducted appropriately and especially in global consensus and led by international experts. As such, the reader has access the important topics required to understand the ulcerative colitis and Crohn's disease.The editors and chapter authors, all established names within gastroenterology and coloproctology, and having extensive experience in assisting patients with inflammatory bowel disease, provide a concise book with quick and objective reference texts that complement the knowledge of students, doctors, nurses, nutritionists and psychologists of daily clinical practice.
Soft Computing and Fuzzy Methodologies in Innovation Management and Sustainability
This book provides recent research on soft computing and fuzzy methodologies in innovation management and sustainability. The uncertainty in the business world is increasing. Significant changes are generated unexpectedly, so using fuzzy logic and soft computing methods allows us to create flexible scenarios adaptable to new realities. Within the book, we will find different applications of fuzzy methodologies that can apply to various topics such as sustainability, innovation, tourism, costs, exports, systems administration, among others. The book's main contribution is the applicability of the various methodologies to specific cases, which allows generating a relationship between theory and practice. In addition, it has some bibliometric studies on various topics that give us a visualization of what has happened and where multiple topics are headed. This book is recommended mainly for students who wish to know how the various fuzzy and soft computing tools can be taken to real situations, allowing a better understanding of these and generating new visions of future applicability.
Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging
Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging, Volume 12 discusses and details almost all aspects of the autophagy machinery in the context of health, cancer and other pathologies. Autophagy is more widely accepted as beneficial given its role in eliminating ‘toxic assets’ and promoting cell viability, hence, it has emerged as a new and potent modulator of disease progression that is both scientifically intriguing and clinically relevant. As the latest release in the Autophagy book series, users will find a detailed explanation of the role of molecular mechanisms. Presents the most advanced information regarding the role of the autophagic system in life and death States recent advancements in the molecular mechanisms underlying a large number of genetic and epigenetic diseases and abnormalities Summarizes the most up-to-date findings on how autophagy is executed and regulated at the molecular level and how its disruption can lead to disease Authored by global leaders in the field, bringing the broadest, most expert coverage available
Luis Leal
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