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The Role of Mini Zinc-Finger Protein in the Replication of the AIDS Virus
Through an investigation of the nucleocapsid protein of the AIDS virus, this book illustrates how a small disordered basic viral protein controls virus structure, replication and genetic variability. It also highlights novel concepts indicating that proteins devoid of a defined 3D structure can have many different roles as mediated by a series of molecular interactions with RNA molecules, and, as such, behave as molecular adaptors.
Diffuse Low-Grade Gliomas in Adults
This book presents the latest research pertaining to the diagnosis, therapy and management of diffuse low-grade gliomas (DLGG) in adults, with a particular focus on the path towards individualised therapy for this kind of tumour. Recent research on the natural history of DLGGs and their interaction with the brain has led to new diagnostic and therapeutic strategies which increase survival and quality of life of the patient, and these methods are described in this book.
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Mechanical Vibrations
Mechanical Vibrations: Theory and Application to Structural Dynamics, Third Edition is a comprehensively updated new edition of the popular textbook. It presents the theory of vibrations in the context of structural analysis and covers applications in mechanical and aerospace engineering. Key features include: A systematic approach to dynamic reduction and substructuring, based on duality between mechanical and admittance concepts An introduction to experimental modal analysis and identification methods An improved, more physical presentation of wave propagation phenomena A comprehensive presentation of current practice for solving large eigenproblems, focusing on the efficient linear solution of large, sparse and possibly singular systems A deeply revised description of time integration schemes, providing framework for the rigorous accuracy/stability analysis of now widely used algorithms such as HHT and Generalized-α Solved exercises and end of chapter homework problems A companion website hosting supplementary material
Neural Metabolism In Vivo
From the preface: “Neural Metabolism In Vivo aims to provide a comprehensive overview of neurobiology by presenting the basic principles of up-to-date and cutting-edge technology, as well as their application in assessing the functional, morphological and metabolic aspects of the brain. Investigation of neural activity of the living brain via neurovascular coupling using multimodal imaging techniques extended our understanding of fundamental neurophysiological mechanisms, regulation of cerebral blood flow in connection to neural activity and the interplay between neurons, astrocytes and blood vessels. Constant delivery of glucose and oxygen for energy metabolism is vital for brain function...
The Making of India
This book presents in a concise format a simplified and coherent geological-dynamical history of the Indian subcontinent (including Sri Lanka, Bangladesh, Myanmar, Southern Tibet and Pakistan). Encompassing a broad array of information related to structure and tectonics, stratigraphy and palaeontology, sedimentation and palaeogeography, petrology and geochemistry, geomorphology and geophysics, it explores the geodynamic developments that took place from the beginning around 3.4 billion years ago to the last about 5,000 years before present. Presented in a distilled form, the observations and deductions of practitioners, this book is meant for teachers, researchers and students of geology, geophysics and geomorphology and practitioners of earth sciences. A comprehensive list of references to original works provides guidance for those seeking further details and who wish to examine selected problems in depth. The book is illustrated with a wealth of maps, cross sections and block diagrams — all simplified and redesigned.
Structure and Tectonics of the Indian Continental Crust and Its Adjoining Region
Structure and Tectonics of the Indian Continental Crust and Its Adjoining Region: Deep Seismic Studies, Second Edition, collates essential data from seismic studies of Earth's crust across India, offering an essential understanding of the tectonic development of the Indian subcontinent. Seismic studies have been carried out in various parts of India since 1972, recording crust-related seismic data for determination of velocity-depth configuration and determination of structural patterns. The book examines the details of these studies, including their synthesis and global applications. The book presents both background and applications in one cohesive volume for researchers and students of geophysics and geology. - Presents all the information and metadata of the Indian continental crust and its neighbouring regions in a cohesive way - Provides basic knowledge of the Indian subcontinent to support the discussion of seismic studies related to crustal structure - Includes all new chapter covering global applications and synthesis of the findings and observations
The Prodigy Slave, Book One
At the age of nine, Lily is forcefully torn from her mother's arms and sold at a Negro auction by her master, a man that Lily learns that day is her very own father. Seeking solace from such devastation, Lily secretly begins teaching herself to play her new master's piano: an instrument that she is forbidden from touching. Lily becomes an extraordinary pianist and gets away with secretly playing for fourteen years until the master's son, James, discovers her deceit. The "punishment" that James gives Lily starts her on an unprecedented journey that dramatically alters her life and influences the lives of thousands, including a man with great power. Lily's groundbreaking journey also unveils the secret altruistic love of a particular man who has been forbidden from expressing his love to her for years. But the question remains whether or not the strength of his love will be powerful enough to free Lily from the shackles of slavery and protect her dreams and her life while on her turbulent Journey to Winter Garden.
Chemical Exchange Saturation Transfer Imaging
This is the first textbook dedicated to CEST imaging and covers the fundamental principles of saturation transfer, key features of CEST agents that enable the production of imaging contrast, and practical aspects of preparing image-acquisition and post-processing schemes suited for in vivo applications. CEST is a powerful MRI contrast mechanism with unique features, and the rapid expansion it has seen over the past 15 years since its original discovery in 2000 has created a need for a graduate-level handbook describing all aspects of pre-clinical, translational, and clinical CEST imaging. The book provides an illustrated historical perspective by leaders at the five key sites who developed C...
