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Tumour microenvironment in cancer research and drug discovery
The implication of tumour microenvironment (TME) on cancer progression and therapeutic response has profoundly shifted the paradigms of molecular cancer research and drug discovery. The intricate networks of immune-inflammatory cells and signalling, cancer-associated fibroblasts, endothelial cells and adipose cells are extensively researched for diagnostics, therapeutics and predictive values. This includes siRNA and miRNA nanotherapeutics targeting these molecular components, owing to their powerful gene-silencing properties. Despite the concerted effort in the development of drug targeting TME, such as BLZ945 (a colony-stimulating factor-1 receptor inhibitor), there is a void in clinically satisfactory drug to target this intricate factor, thus far.
DIGITAL TRANSFORMATION IN EMERGING BUSINESS ENVIRONMENT
The National Level Peer Reviewed Edited Book titled ‘Digital Transformation in Emerging Business Environment’ is a wonderful treatise which concentrates on the efficiency of improved infrastructure and its impact on the socio-economic growth and addresses diverse theme of great importance and relevance to the business, economy and society. This book contains research papers and scholarly articles of the eminent academicians, scholars and researchers in the diverse fields of Business, Finance, Marketing, Management etc. in a highly organised and lucid manner.
The Unheard Soul
This book 'The Unheard Soul' features writings of writers all over the globe. It comprises of distinct topic in exotic genres with emotions expressed in simplicity. This book can be proved as the best way to lighten up your soul and brighten up your day with positivity. This anthology provides a platform to the budding writers to showcase their talent, to express their unheard soul! This book is successful in fabricating the dedication and devotion towards literature among the young and passionate writers and inspires many to explore their inner potential!
The Role of non-coding RNAs in Gastrointestinal Cancers
Gastrointestinal malignancies encompass a large number of tumor types, and collectively are responsible for a significant portion of new cancer cases annually. According to the IARC database, colorectal cancer alone is responsible for approximately 10% of new cases of cancer worldwide annually. There is significant heterogeneity across the various tumor types, with different pathways and factors involved in oncogenesis, as well as varying degrees of prognosis depending on the tumor type. Non-coding RNAs (ncRNAs) contribute to a significant portion of the human transcriptome, and of particular interest are the micro-RNAs (miRNAs), long ncRNAs (lncRNAs), and circular ncRNAs (circRNAs). With the advent of next-generation sequencing and new technologies such a minimally invasive biopsy techniques, there is a growing body of evidence elucidating the role of ncRNAs in the progression of various form of gastrointestinal cancers. Furthermore, in addition to their relevance to cancer progression, these ncRNAs have important potential as biomarkers and prognostic markers for various GI cancers.
Women in Cancer Imaging and Image-directed Interventions: 2021
We are delighted to present the inaugural Frontiers in Oncology "Women in Cancer Imaging and Image-directed Interventions” series of article collections. At present, less than 30% of researchers worldwide are women. Long-standing biases and gender stereotypes are discouraging girls and women away from science-related fields, and STEM research in particular. Science and gender equality are, however, essential to ensure sustainable development as highlighted by UNESCO. In order to change traditional mindsets, gender equality must be promoted, stereotypes defeated, and girls and women should be encouraged to pursue STEM careers.
