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Understanding the Crosstalk Between Immune Cells and the Tumor Microenvironment in Cancer and Its Implications for Immunotherapy
One of the current challenges and failures of immunotherapy is in part due to the complex tumor microenvironment (TME) that provides a formidable barrier to immune infiltration and function. The TME consists of various cell types (tumor cells, fibroblasts, endothelial cells, and immune cells), soluble signaling molecules (cytokines, growth factors, and chemokines), and extracellular matrix. On another note, metabolic disturbances in various TME components, such as hypoxia, acidosis, lactate accumulation, and nutrient deprivation, can play a critical role in the tumor progression. Furthermore, genetic and epigenetic dysfunctions are known to be part of the characteristics of cancer development. The immune cells could have a pro- or anti-tumor role in the TME, and their activity might vary in the context of different cancers. Both innate and adaptive immune cells interact with tumor cells through direct contact or through chemokines and cytokines signaling, shaping the tumor's activity and response to therapy.
Serious Games
This book constitutes the proceedings of the Third Joint International Conference on Serious Games, JCSG 2017, held in Valencia, Spain, in November 2017. This conference bundles the activities of the 8th International Conference on Serious Games Development and Applications, SGDA 2017, and the 7th Conference on Serious Games, GameDays 2017. The total of 23 full papers, 3 short papers, and 4 poster papers was carefully reviewed and selected from 44 submissions. The topics covered by the conference offered participants a valuable platform to discuss and learn about the latest developments, technologies and possibilities in the development and use of serious games with a special focus on how different fields can be combined to achieve the best possible results.
Arabic and contact-induced change
This volume offers a synthesis of current expertise on contact-induced change in Arabic and its neighbours, with thirty chapters written by many of the leading experts on this topic. Its purpose is to showcase the current state of knowledge regarding the diverse outcomes of contacts between Arabic and other languages, in a format that is both accessible and useful to Arabists, historical linguists, and students of language contact.
Introduction to Arabic Natural Language Processing
This book provides system developers and researchers in natural language processing and computational linguistics with the necessary background information for working with the Arabic language. The goal is to introduce Arabic linguistic phenomena and review the state-of-the-art in Arabic processing. The book discusses Arabic script, phonology, orthography, morphology, syntax and semantics, with a final chapter on machine translation issues. The chapter sizes correspond more or less to what is linguistically distinctive about Arabic, with morphology getting the lion's share, followed by Arabic script. No previous knowledge of Arabic is needed. This book is designed for computer scientists and linguists alike. The focus of the book is on Modern Standard Arabic; however, notes on practical issues related to Arabic dialects and languages written in the Arabic script are presented in different chapters. Table of Contents: What is "Arabic"? / Arabic Script / Arabic Phonology and Orthography / Arabic Morphology / Computational Morphology Tasks / Arabic Syntax / A Note on Arabic Semantics / A Note on Arabic and Machine Translation
Heavy Construction of Infrastructure. How to Choose the Right Method?
Document from the year 2016 in the subject Engineering - Civil Engineering, language: English, abstract: The construction of infrastructures like bridges, tunnels, pipelines, elevated tanks, underground structures, hydraulic structures and caissons involves heavy construction activities. Each type of these structures involves activities categorized as heavy construction activities that involve capital intensiveness, non-conventional equipment and non-typical construction technology. Hence, constructing such infrastructures requires certain level of know-how that may not be easily available within average engineers and contractors. The choice between the different construction methods within ...
A Lab of My Own
What was it like to be a woman scientist battling the “old boy's” network during the 1960s and 1970s? Neena Schwartz, a prominent neuroendocrinologist at Northwestern University, tells all. She became a successful scientist and administrator at a time when few women entered science and fewer succeeded in establishing independent laboratories. She describes her personal career struggles, and those of others in academia, as well as the events which lead to the formation of the Association of Women in Science, and Women in Endocrinology, two national organizations, which have been successful in increasing the numbers of women scientists and their influence in their fields.The book intersper...
Delineating Health and Health System: Mechanistic Insights into Covid 19 Complications
This book discusses the organ-specific systemic manifestations of COVID-19. The initial chapters of the book review the origin and evolution of the coronaviruses, followed by pathogenesis and immune response during COVID-19 infection. The book also provides insight into the role of angiotensin-converting enzyme 2 in the onset of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pathogenesis. It summarizes the neurological aspects of SARS-CoV2, including transmission pathways, mechanisms of invasion into the nervous system, and mechanisms of neurological disease. It also delineates the association of severe disease with high blood plasma levels of inflammatory cytokines and inflammatory markers in SARS-CoV-2 infection. Lastly, it discusses the perturbation of gut microbiota by SARS-CoV-2 and uncovers the potential risk of virus infection on reproductive health.
