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Cardiac Regeneration and Repair, Volume One reviews the pathology of cardiac injury and the latest advances in cell therapy. Chapters in part one explore the pathogenesis of congestive heart failure, the mechanisms responsible for adverse cardiac matrix remodeling, and potential interventions to restore ventricular function. Part two highlights new approaches to cell therapy for cardiac regeneration, and includes chapters covering alternative routes of cell delivery, monitoring cell engraftment, and the feasibility of using allogeneic stem cells to restore cardiac function. Chapters in part three move on to highlight novel stem cells for cardiac repair, including human embryonic stem cells a...
Cardiac Regeneration and Repair, Volume Two reviews the use of biomaterials, alone or combined with cell therapy, in providing tissue-engineered constructs to repair the injured heart and prevent or reverse heart failure. Part one explores the variety of biomaterials available for cardiac repair, including nanomaterials and hydrogels. Further chapters explore the use of biomaterials to enhance stem cell therapy for restoring ventricular function and generating stem cell-modified intravascular stents. Part two focuses on tissue engineering for cardiac repair, including chapters on decellularized biologic scaffolds, synthetic scaffolds, cell sheet engineering, maturation of functional cardiac ...
I am very pleased to present this volume on engineering stem cells in Advances in Biochemical Engineering and Biotechnology. This volume stays abreast of recent developments in stem cell biology and the high expectations concerning the dev- opment of stem cell based regenerative therapies. Regenerative medicine is the focus of current biomedical research, with unique challenges related to scientific, technical and ethical issues of stem cell research, and the potential added value of connecting biomedicine with enabling techno- gies such as materials sciences, mechanical- and nano-engineering. Research activities in regenerative medicine include strategies in endogenous regeneration of injur...
The University of Toronto’s Faculty of Medicine is North America’s largest medical school and a major health consortium, boasting nine affiliated teaching hospitals and a network of research institutes. It is where insulin was pioneered, stem cells were first discovered, and famous physicians from Vincent Lam to Sheela Basrur began their careers. But despite all its major accomplishments, the faculty’s impressive history has never before been comprehensively documented. In Partnership for Excellence, senior medical historian and award-winning author Edward Shorter details the Faculty of Medicine’s history from its inception as a small provincial school to its present day status as an international powerhouse. Deeply researched through front-line interviews and primary sources, it ties the story of the faculty and its teaching hospitals to the general history of medicine over this period. Shorter emphasizes the enormous concentration of intellectual energy in the faculty that has allowed it to become the dominant force in Canadian medicine, home to a legion of medical pioneers and achievements.
The American Heart Association’s Scientific Sessions 2016 is bringing big science, big technology, and big networking opportunities to New Orleans, Louisiana this November. This event features five days of the best in science and cardiovascular clinical practice covering all aspects of basic, clinical, population and translational content.
Great innovations take place within great institutions. Founded in 1819, Toronto General Hospital (TGH) is one of Canada’s oldest hospitals and has created a nurturing environment for early Canadian innovations in heart surgery. The Heartbeat of Innovation tells the story of the brilliant surgeons who worked there and the hospital environment that provided an incubator to the many people – skilled perfusionists, dedicated nurses, and pioneering cardiologists – who participated in the revolution in heart surgery that took place along University Avenue in Toronto. Supported by historical records, hospital archives, personal memoirs, and interviews, this book is an extensive and descripti...
The human body contains many specialized tissues that are capable of fulfilling an incredible variety of functions necessary for our survival. This volume in the Human Cell Culture Series focuses on mesenchymal tissues and cells. The in vitro study of mesenchymal cells is perhaps the oldest form of human cell culture, beginning with the culturing of fibroblasts. Fibroblasts have long been generically described in the literature, arising from many tissue types upon in vitro cell culture. However, recent studies, many enabled by new molecular biology techniques, have shown considerable diversity in fibroblast type and function, as described within this volume. Mesenchymal tissue types that are...
Virtually any disease that results from malfunctioning, damaged, or failing tissues may be potentially cured through regenerative medicine therapies, by either regenerating the damaged tissues in vivo, or by growing the tissues and organs in vitro and implanting them into the patient. Principles of Regenerative Medicine discusses the latest advances in technology and medicine for replacing tissues and organs damaged by disease and of developing therapies for previously untreatable conditions, such as diabetes, heart disease, liver disease, and renal failure.* Key for all researchers and instituions in Stem Cell Biology, Bioengineering, and Developmental Biology* The first of its kind to offer an advanced understanding of the latest technologies in regenerative medicine* New discoveries from leading researchers on restoration of diseased tissues and organs
The fields of stem cell research, regenerative medicine, tissue engineering, and cloning are very closely related. It is important for researchers in each of these disciplines to be aware of the methods and principles in the others. Elsevier publishes some of the highest individual references in these areas. Bringing together the principles, applications, and basic understanding in these related areas of science will provide a new reference which is serve the needs of a variety of researchers. Edited by Dr. Bruce Carlson, Stem Cell Anthology will be valuable to researchers and students who need to save time and link concepts to principles, applications, and methods in order to work more effe...