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Lysosomes are membrane-surrounded organelles which are present in all animal cells. The importance of this organelle is underlined by an increasing number of human diseases, which are associated with an impaired function of the lysosomal compartment. This book summarizes the current state-of-the art knowledge about this unique organelle. It addresses the biogenesis of this compartment, the transport of lysosomal proteins, the role of the lysosomal membrane in lysosomal stability and transport, the function of lysosomal proteases and hydrolases, lysosomal storage disorders, and new concepts on how to treat these diseases. In addition to these classical topics, new insights into lysosomal functions are covered by chapters dealing with specialized lysosomes involved in bone resorption and plasma membrane repair, the lysosomal transciptome, and proteome and the emerging role of lysosomes in special forms of autophagy. This book will provide readers with a comprehensive overview into how this fascinating organelle works and how research in the field is developing.
Now in its sixth edition, Color Atlas of Physiology covers the entire subject of human physiology and brilliantly reviews everything medical students need to know to pass their pre-clinical physiology exams. Sections include the nerves and muscles, blood, respiration, the cardiovascular system, digestion, and reproduction. Providing a concise review of each thematic unit, the popular and proven layout of the book's double-page spreads with color illustrations and accompanying text allows for speedy comprehension and recall of key concepts. This new edition includes recent scientific developments, especially regarding the successful application of molecular biology and gene technology concept...
Remarkable atlas provides exceptionally detailed, clinically relevant anatomic knowledge! Praise for the prior edition: "The THIEME Atlas of Anatomy – Internal Organs provides pertinent and well-executed anatomical illustrations, enriched with figures from diagnostic imaging. We strongly suggest this atlas not only to students in medicine, but also to residents and practitioners, including those involved in diagnostic imaging."—European Journal of Nuclear Medicine and Molecular Imaging Thieme Atlas of Anatomy: Internal Organs, Third Edition by renowned educators Michael Schuenke, Erik Schulte, and Udo Schumacher, along with consulting editor Wayne Cass, expands on prior editions with inc...
Remarkable atlas provides exceptionally detailed, clinically relevant anatomic knowledge! Thieme Atlas of Anatomy: Internal Organs, Third Edition, Latin Nomenclature, by renowned educators Michael Schuenke, Erik Schulte, Udo Schumacher, along with consulting editors Wayne Cass and Hugo Zeberg, expands on prior editions with increased detail on anatomic relationships of inner organs, and the innervation and lymphatic systems of these organs. Organized by region, the book features 10 sections starting with an overview on body cavities. Subsequent sections cover the cardiovascular, blood, lymphatic, respiratory, digestive, urinary, genital, endocrine, and autonomic nervous organ systems. Region...
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Ce volume rassemble les textes des communications faites lors du symposium organisé à Rouen les 23 et 24 mai 1985. Au cours de ce colloque sur l'hépatotoxicité, les sujets suivants ont été abordés : les aspects chimiques et anatomopathologiques des hépatites aiguës et chroniques d'origine médicamenteuse, les méca¬nismes d'action (qui ont occupé la plus grande partie de ces communications), les mécanismes de protection cellulaire vis-à-vis de certains métabolites toxiques, la quantification de la toxicité hépatique... Il est impossible de tout citer mais il est certain que l'ouvrage constitue un excellent document de travail pour tous ceux qui sont préoccupés par ce problème de l'hépatotoxicité tant expérimentale qu'humaine.
The International Life Sciences Institute (ILSI) was established in 1978 to stimulate and support scientific research and educational programs related to nutrition, toxicology, and food safety, and to encourage cooper ation in these programs among scientists in universities, industry, and government agencies to assist in the resolu tion of health and safety issues. To supplement and enhance these efforts, ILSI has made a major commitment to supporting programs to har monize toxicologic testing, to advance a more uniform in terpretation of bioassay results worldwide, to promote a common understanding of lesion classifications, and to encourage wide discussion of these topics among scien tists...
Histologie de Lullmann-Rauch est un condensé illustré d'histologie qui décrit la cytologie, l'histologie générale et l'anatomie microscopique ("histologie spéciale") de manière remarquablement exhaustive. Le contenu, bien à jour, correspond à tout ce qu'un étudiant en médecine doit savoir pour commencer l'étude de l'anatomie pathologique, et à tout ce qu'un médecin devrait en principe comprendre pour lire les rapports et les diagnostics établis par les pathologistes. Les aspects fonctionnels (biochimie, biologie moléculaire, physiologie) sont toujours repris en rapport avec les aspects morphologiques, et leur liaison avec la clinique est souvent explicitée. De plus, on trouve beaucoup d'exemples cliniques dont certains font référence à des maladies ou à des syndromes rares, ce qui permet au lecteur/étudiant de prendre conscience de l'importance du sujet - et de sa connaissance approfondie - pour la pratique médicale.