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GLASS: the detection and reporting of colistin resistance
This document reviews current methods for the detection of colistin resistance and provides a framework for its investigation. The document highlights the critical distinction between phenotypic detection of colistin resistance and genotypic detection of specific colistin resistance mechanisms, such as mcr and chromosomal mutations. Colistin resistance in Enterobacterales and Acinetobacter baumannii is included in the WHO Global Antimicrobial Resistance Surveillance System (GLASS). Currently, however, reliable tests for phenotypic detection of colistin resistance for clinical and surveillance purposes are not widely available. The document describes existing phenotypic methods for detecting colistin resistance, genotypic methods for detecting specific colistin resistance mechanisms and surveillance strategies for monitoring colistin resistance.
Antimicrobial Resistance in Zoonotic Bacteria
Due to the extensive antimicrobial use in humans and agriculture, antimicrobial resistance (AMR) has emerged as a major threat to global health. The intensive use of antimicrobials in animals selects AMR genes, which then can be transferred to human pathogens via a variety of horizontal gene transfer mechanisms. Although the prevalence and mechanisms of AMR have been studied in common foodborne pathogens and indicator bacteria such as Escherichia coli, Staphylococcus aureus, and the species of Enterococcus, Salmonella, and Campylobacter, the situation with other rarely investigated veterinary and zoonotic bacteria such as Leptospira, Brucella, Borrelia, Lawsonia and other genera is less clear. In addition, the majority of surveillance and control programs have been designed to target commensal and zoonotic bacteria in food production animals, thus AMR bacteria in companion, wild and other animals have received less attention.
The Political Economy of Disaster
Haiti, one of the least developed and most vulnerable nations in the Western Hemisphere, made the international headlines in January 2010 when an earthquake destroyed the capital, Port-au-Prince. More than a year later, little reconstruction has taken place, in spite of a strong international funding commitment. Mats Lundahl has written several seminal works on Haiti, and this volume brings together the best of his past work on Haiti’s economic and political history, along with a comprehensive introduction and two new chapters which bring the story right up to the present day. Together, the volume provides both historical background and explanation as to why Haiti was so badly affected by ...
Whole genome sequencing as a tool to strengthen foodborne disease surveillance and response. Module 1
Globally, there is growing recognition of foodborne diseases as a public health priority. From a public health perspective, foodborne diseases are largely preventable, and can be controlled through effective food safety systems that evaluate hazards along the food chain, from production to consumption. An integrated food chain surveillance system can detect and monitor foodborne bacteria, including antimicrobial resistant bacteria, throughout the food chain. Whole genome sequencing (WGS) has the potential to change how we detect and monitor microbial hazards in the food chain, as well as how we assess, investigate and manage food safety risks. It is anticipated that this new technology will ...
