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Access to relevant external knowledge is crucial for a firms' competitiveness in innovation-driven industries. This thesis focuses on how different forms of proximity affect a firm's ability to access such knowledge. We consider the influence of being co-located in space, of being embedded in a network, and of being active in similar knowledge domains. By integrating these three proximity perspectives, we contribute to various disciplines such as economic geography, organizational sociology and innovation studies. Further, we investigate the make, buy or ally strategies that pharmaceutical firms employ to maximize the probability of innovation (finding new drugs). Our findings suggest that firms employ multiple governance structures simultaneously, even when targeting similar innovations. These insights contribute to our understanding of the boundaries of the firm.
This textbook provides a comprehensive and state-of-the-art overview of the major issues specific to the field of pediatric gastroenterology, hepatology, and nutrition. The first part of the book, Gastroenterology and Nutrition, presents in a systematic way the overall scope of issues encountered by children (newborn to teenagers) suffering from disorders of the gastrointestinal tract, pancreas and/or presenting nutritional issues. These chapters are structured in logical sections to facilitate consultation and include major topics ranging from congenital disorders to gastrointestinal problems of the newborn, infectious diseases of the gastrointestinal tract, and approach to nutritional prob...
This clinical casebook is comprised of surgical cases involving the most important cardiovascular diseases in a concise, easy-to-read format (5x8 in trim size, like other titles in this burgeoning, informal product line in the Springer clinical medicine program). Each chapter is a case that opens with a unique clinical presentation, followed by a description of the diagnosis, assessment and management techniques used to treat it, as well as questions and answers (between 8 and 10) about relevant aspects related to the diagnosis and treatment of the addressed disease. The Q&A section will broaden discussion and increase the title's pedagogical value. The casebook features 40 surgical cases in...
This book captures cornerstone developments in a new body of knowledge and provides an expert resource on a “hot topic” in rectal surgery. Transanal minimally invasive surgery (TAMIS) was designed for local excision of select rectal neoplasms, however soon it became realized that the TAMIS technique could be used for applications beyond local excision, most notably for transanal total mesorectal excision (taTME). This new operative technique has revolutionized our approach to the distal rectum by allowing for improved access, especially in obese male patients with an android pelvis, and by minimizing abdominal wall access trauma. The endpoints of improved oncologic resection, as defin...
Accelerated partial breast irradiation (APBI) is being rapidly introduced into the clinical management of early breast cancer. APBI, in fact, encompasses a number of different techniques and approaches that include brachytherapy, intraoperative, and external beam techniques. There is currently no single source that describes these techniques and their clinical implementation. This text is a concise handbook designed to assist the clinician in the implementation of APBI. This includes a review of the principles that underlie APBI, a practical and detailed description of each technique for APBI, a review of current clinical results of APBI, and a review of the incidence and management of treatment related complications.
Intelligent Information Processing supports the most advanced productive tools that are said to be able to change human life and the world itself. This book presents the proceedings of the 4th IFIP International Conference on Intelligent Information Processing. This conference provides a forum for engineers and scientists in academia, university and industry to present their latest research findings in all aspects of Intelligent Information Processing.
This volume delivers a selection of papers presented at an international teaching conference on issues of theory and practice. These key topics will be of interest to novice and veteran teachers, policy makers and all education professionals.
Modern medical imaging and radiation therapy technologies are so complex and computer driven that it is difficult for physicians and technologists to know exactly what is happening at the point-of-care. Medical physicists responsible for filling this gap in knowledge must stay abreast of the latest advances at the intersection of medical imaging an
MOLECULAR ENZYMOLOGY, BECAUSE OF ITS CHEMICAL AND MATHEMATICAL content, is often regarded as a formidable and forbidding topic by undergraduates on a biology or biochemistry course, As a result of teaching enzymology to undergraduates for a number of years, we recognize the areas which appear to cause the most common difficulties in conceptual understanding. We feel that a book treating those areas by means of a logical approach carefully developed from basic principles fills a gap in the multiplicity of enzymology texts currently available. In writing this book we h;:lVe had in mind the needs of Honours Biochemistry students, in particular those who may take a special interest in enzymology...
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