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Hearing Loss: Mechanisms, Prevention and Cure
  • Language: en
  • Pages: 182

Hearing Loss: Mechanisms, Prevention and Cure

  • Type: Book
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  • Published: 2019-03-26
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  • Publisher: Springer

This book systematically discusses the pathogenesis, prevention, and the current and potential clinical treatment of hearing loss, as well as the latest advances in hearing research. Hearing loss is a prevalent sensory disorder, which according to a 2015 World Health Organization (WHO) report affected 9% of the global population in 2015. As populations continue to age, more and more people are suffering from the condition, with 60% of those aged between 65 and 75 affected. Hearing loss seriously affects patients’ ability to work ability and quality of life, and as such deafness has become an increasingly urgent social problem around the globe. Sensorineural hearing loss is mainly caused by damage to the hair cells (HCs), and the subsequent loss of spiral ganglion neurons (SGNs). Damage to the HCs in the inner ear can result from exposure to loud noises and environmental and chemical toxins as well as genetic disorders, aging, and certain medications. This book provides ENT specialists and researchers, as well as individuals affected a comprehensive introduction to the field of hearing loss.

Synaptic Assembly and Neural Circuit Development
  • Language: en
  • Pages: 191

Synaptic Assembly and Neural Circuit Development

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Sensory Hair Cell Death and Regeneration
  • Language: en
  • Pages: 268

Sensory Hair Cell Death and Regeneration

Sensory hair cells are the specialized mechanosensory receptors found in vertebrate auditory, vestibular, and lateral line organs that transduce vibratory and acoustic stimuli into the sensations of hearing and balance. Hair cells can be damaged due to such factors as aging, ototoxic chemicals, acoustic trauma, infection, or genetic factors. Loss of these hair cells lead to deficits in hearing and balance, and in mammals, such deficits are permanent. In contrast, non-mammalian vertebrates exhibit the capability to regenerate missing hair cells. Researchers have been examining the process of hair cell death and regeneration in animal models in an attempt to find ways of either preventing hair...

Hearing Loss: Mechanisms and Prevention
  • Language: en
  • Pages: 447

Hearing Loss: Mechanisms and Prevention

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The Mechanism on Development and Regeneration of Inner Ear Hair Cells
  • Language: en
  • Pages: 139

The Mechanism on Development and Regeneration of Inner Ear Hair Cells

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Gene therapy for hearing loss: From mechanism to clinic
  • Language: en
  • Pages: 156

Gene therapy for hearing loss: From mechanism to clinic

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Biomaterials for Engineering Cellular Environments in Tissue Engineering
  • Language: en
  • Pages: 188
New Therapies to Prevent or Cure Auditory Disorders
  • Language: en
  • Pages: 189

New Therapies to Prevent or Cure Auditory Disorders

Hearing loss is the most common form of sensory impairment in humans, affecting 360 million persons worldwide. In parallel, tinnitus disorder, the perception of a phantom sound often described as a ringing or buzzing, affects around 10–15% of the general population and interferes with daily life. Hyperacusis, defined as a hypersensitivity to moderate-intensity sounds often co-occurs with tinnitus suggesting a common mechanism of dysfunction for these two perceptual disorders. Whereas some drug candidates are in the process of being developed, nowadays no effective treatment exists to cure hearing loss and tinnitus. The topic of this book was selected with the goal of emphasizing mechanisms...

Gene therapy for hearing loss: From mechanism to clinic, volume II
  • Language: en
  • Pages: 124