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This succinct text fills the demand for a resource covering the pathology of cardiovascular diseases. Addresses ischemic heart disease, reviewing the many recent advances that have led to new concepts in cardiovascular pathology and pathophysiology. Emphasizes general approaches to heart examination and outlines expectations and limitations of pathologic assessment of cardiovascular disease. Written by well-known experts in the field, this 2nd Edition is completely updated and efficiently reorganized to be more concise and streamlined. Offers the expertise of two new authors-Allen Burke, MD and Andrew Farb, MD Presents brand-new chapters on Coronary Heart Disease and Its Syndromes Pathology of Vascular Interventions Pericardial Diseases Cardiac Tumors and Diseases of the Aorta Features meticulous updates throughout as well as completely up-to-date references Contains many new color plates and illustrations.
The pre-eminent reference on coagulation disorders is now in its thoroughly updated Fifth Edition. Written by more than 160 of the world's foremost authorities, this encyclopedic volume integrates basic science and clinical practice and details all that is currently known about blood clotting disorders and how to manage patients with these and related problems. This edition has been reorganized into smaller, more tightly focused chapters to help readers find information easily. A new co-editor, Samuel Z. Goldhaber, MD, has expanded the cardiology portion of the book. Other new features include a two-color page design and more than 100 full-color illustrations.
Despite recent advances in the diagnosis and treatment of symptomatic atherosclerosis, available traditional screening methods for early detection and treatment of asymptomatic coronary artery disease are grossly insufficient and fail to identify the majority of victims prior to the onset of a life-threatening event. In Asymptomatic Atherosclerosis: Pathophysiology, Detection and Treatment, Dr. Morteza Naghavi and leading authorities from the Society for Heart Attack Prevention and Eradication (SHAPE) present a new paradigm for the screening and primary prevention of asymptomatic atherosclerosis. The text focuses on accurate, yet underutilized, measures of subclinical atherosclerosis, notabl...
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This is the handbook that professionals who deal with problems related to drugs and drug abuse have been waiting for. The impressive list of more than 80 contributors, each experts and leaders in their field, testifies to the importance of this outstanding new handbook. The volume contains detailed discussions of drug-related issues in criminalistics, pathology, and toxicology. Impairment testing and the pharmacokinetics of abused drugs are examined in detail, as is the field of workplace drug testing, the use of alternate testing matrices, drugs in sports, addiction medicine, and drug-related medical emergencies. The handbook focuses on the most urgent drug abuse-related problems of today A...
Beginning with a definition and explanation of scheduling of controlled substances, Pathology, Toxicogenetics, and Criminalistics of Drug Abuse covers investigative methods for all illegal drugs and several legitimate pharmaceuticals that are used illicitly, including steroids. It covers the latest techniques used to analyze drugs in the forensic laboratory including physical characteristics and chemical confirmatory tests. It discusses new theories and findings in toxicogenetics, details pathologic changes in the body due to drug use, and examines specific effects on the heart, lung, and central nervous system. More that 70 tables and figures illustrate and complement the text and the information is supported by extensive references
Over the last decades cell biology and biological chemistry have increasingly turned their attention to the space between cells and revealed an elaborate network of macromolecules essential for structural support, cell adhesion and signaling. This comprehensive handbook of the extracellular matrix will give an overview of the current state of knowledge of matrix components (structure and function), their role in heath and disease (matrix pathobiology) and new aspects related to pharmacological targeting. It will provide an introduction to the extracellular matrix and detailed sections and chapters on: Importance of extracellular matrix in health and disease Matrix proteoglycans (aggrecan, ve...
Cardiovascular diseases continue to be the leading cause of death in the - jority of industrialized countries. The most frequent underlying pathology, namely atherosclerosis, and its clinical sequelae, namely coronary heart d- ease, cerebrovascular disease and peripheral artery disease, remain common although for a long time we have been made aware of avoidable or mo- ?able etiological factors such as smoking, fat-rich diet or lack of exercise, and although these adverse lifestyle factors have been extensively addressed by population-wide primary prevention programs. Cardiovascular morbidity and mortality also remain high despite successful anti-hypertensive and lipid lowering drug therapies...
This book is ideal for cardiovascular imagers of all backgrounds as well as proceduralists (surgeons and interventional cardiologists) performing TAVR. This text is also of value for the physicians and nurses involved in the care of these patients, and for fellows-in-training. This practical text brings together guidance on using multi-modality imaging in one book and highlights its usage with a focus on patient care. Pre-procedural, Intra-procedural and Long-term follow up), this review offers expert opinion and evidence-based guidance on how to incorporate the various imaging modalities at each step in the care of a TAVR patient. Although much has been learned in the short span of time since TAVR was introduced into the field, our book will also offer recommendations for clinically-relevant research areas that will lead to best practice strategies for incorporating multi-modality imaging into TAVR patient care.
This book will consider several clinical and interventional topics for which there is uncertainty, continued debate and/or no consensus based on current guidelines. While there are numerous guidelines in cardiology, new and on-going trials that address new drugs treatments and procedures raise many unanswered questions. Furthermore, most practicing cardiologist taking care of the patients are likely unable to digest all of these studies or guidelines and necessarily correctly apply them to their patients. If one considers in the guidelines the frequent use of Level C (consensus), there are many areas or situations where no trial exists. Also, when applying the results of a trial to an individual patient, there can be uncertainty of how this patient should be managed based on the present body of evidence.