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Roving vigilantes, fear-mongering politicians, hysterical pundits, and the looming shadow of a seven hundred-mile-long fence: the US–Mexican border is one of the most complex and dynamic areas on the planet today. Hyperborder provides the most nuanced portrait yet of this dynamic region. Author Fernando Romero presents a multidisciplinary perspective informed by interviews with numerous academics, researchers, and organizations. Provocatively designed in the style of other kinetic large-scale studies like Rem Koolhaas's Content and Bruce Mau’s Massive Change, Hyperborder is an exhaustively researched report from the front lines of the border debate.
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This volume discusses various aspects of mechanisms and methodologies of chromosome translocations, ranging from a historical and clinical overview of chromosome translocations to the rapid development of the next-generation sequencing technologies, which has dramatically increased our understanding of the spectrum of chromosome translocations in human diseases. The book also introduces the mechanistic studies on chromosome deletions and their implications in cancer, and discusses the mechanisms of regulating chromothripsis, a unique complex type of chromosome translocation. It is a valuable resource for students and researchers alike, providing insights into chromosome translocations and, potentially, other genomic aberrations involved in understanding and curing human diseases.