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If you feel that the current political divisions are harming our country, this book is for you because it provides a science-based, stepwise, approach to build constructive partisanship and re-learn how to engage with and live with political disagreements. Because its approach appeals to our reason as well as our emotions those who reviewed this book found it "transformative."
Despite the well-established consensus on the need for an interdisciplinary research paradigm to understand the unfolding of human lives within their social context, existing empirical research rarely embraces this belief. This volume aims at examining the feasibility and hurdles of interdisciplinarity specific to given research fields by bringing together leading North-American and European researchers in sociology, psychology, social psychology and social demography, all highly concerned with fostering an interdisciplinary perspective for the study of the human life course. The contributions are organized along four major axes, three of them substantive (agency and structure, transitions, ...
This volume brings together the large body of recent research on metabolic drug interactions and their relevance in the treatment of diseases. The book focuses on human metabolic enzyme systems that have been shown in vitro to be predictive of drug interactions. Major sections present information on specific therapeutic classes of drugs as substrates, inhibitors, and inducers of metabolic enzymes. Other chapters discuss the clinical and pharmacoeconomic implications of metabolic drug interactions and the significance of in vitro metabolic studies in new drug development.
Volume 95 of International Review of Neurobiology focuses on Catechol-O-methyltransferase inhibition, and its clinical application in relation to Parkinson's disease. Chapters cover COMT gene and proteins, L-dopa treatment in Parkinson's disease, the latest research on COMT inhibitors and their clinical applications, as well as future prospects for their use. - Up-to-date summary of biochemistry and pharmacology of COMT and its inhibitors - Preclinical models in COMT inhibitor devlopment - Transgenic COMT mice – latest information summarized - Chemistry of COMT inhibitors and their design with molecular modelling - COMT gene and its regulation and relation to dopamine related diseases - Role of cofactor SAM regulation in relation to homocysteine - Nonclinical and clinical safety of COMT inhibitors summarized - Future prospects of COMT inhibitors in Parkinson's disease
Published since 1959, International Review of Neurobiology is a well-known series appealing to neuroscientists, clinicians, psychologists, physiologists, and pharmacologists. Led by an internationally renowned editorial board, this important serial publishes both eclectic volumes made up of timely reviews and thematic volumes that focus on recent progress in a specific area of neurobiology research. This volume reviews existing theories and current research surrounding the movement disorder Dyskinesia. - Leading authors review state-of-the-art in their field of investigation and provide their views and perspectives for future research - Chapters are extensively referenced to provide readers with a comprehensive list of resources on the topics covered - All chapters include comprehensive background information and are written in a clear form that is also accessible to the non-specialist
This book, first published in 2005, introduces measure and integration theory as it is needed in many parts of analysis and probability.