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I was looking at Mrs T – all 45 kilos of her – with somewhat puzzled thoughts. I had prescribed her capecitabine at very prudent doses, in view of her 91-year-old kidneys and physiology. She had reduced my treatment even further, “because it was making her tired.” As a result, she was taking a grand total of 500 mg of capecitabine a day. Yet, her metastatic, ER/PR-negative, Her2-positive breast cancer was undoubtedly responding. Her pain was improving and her chest mass was shrinking, as were her lung metastases... What was the secret of that response? Were Mrs T’s kidneys eli- nating even less drug than predicted by her creatinine clearance? Was her sarcopenia altering drug distri...
Surgical oncology is now a recognized specialty in the US and several European countries, and cancer surgery takes up a significant part of any general surgeon’s workload. This thoroughly updated second edition of this bestseller is officially endorsed as a textbook for the syllabus and curriculum of the UEMS examination in Surgical Oncology, which is administered by ESSO (European Society for Surgical Oncology). The examination is for trainees at the end of training or established consultants seeking to expand their accreditation.
Geriatric Surgery and Perioperative Care presents clear evidence to support regulatory and financial decisions in the light of the value-based care principles. It outlines standards of care for elderly patients undergoing surgery as well as the minimal requirements for modern management aimed to deliver cost-effective healthcare. The book opens with the epidemiology and patho-physiological changes of aging and their impact on anesthesia and surgery. Subsequent chapters guide readers through the surgical process, addressing preoperative optimization, intraoperative procedures and management, postoperative principles, including ICU care. The book concludes with ethical principles, care models, and hospital design to support a golden silver surgery using a team-based approach. This title is an important resource for healthcare professionals, practitioners, and others pursuing current strategies and methods for successful perioperative care of the elderly.
This unique book presents a series of concisely written technical notes on the most common surgical oncology procedures. Each procedure is illustrated with pictures framing the precise technical point of the procedure. The book is accompanied by a CD-ROM that includes video clips of the procedures.Written by top European experts, this volume will provide an invaluable resource for young surgical oncologists to study and critically approach the basic technicalities of surgical procedures. It will also be a useful source of reference for oncologists, surgeons, radiotherapists, surgical oncologists and nurses, as well as final-year medical students.
An integrated survey of best practices for the management of patients with implanted prosthetic devices and an insightful examination of the epidemiological, societal, and policy issues associated with their use. The devices covered range from breast, penile, vascular, and joint prostheses to cochlear, ossicular, and dental implants, and include cerebrospinal fluid shunts, cardiac valves, stents, and pacemakers. For each device, the authors consider its pros and cons, detail the best current strategies to keep implanted patients healthy, and evaluate the latest and most promising new diagnostic tests, Clinical counterpoints from distinguished authorities at major centers in the United States and Europe are offered throughout. Follow-up recommendations are summarized in a standardized format that allows comparative analysis and lays the foundation for controlled clinical trials and the eventual establishment of evidence-based guidelines.
This atlas presents state-of-the-art visual guidance on today's full range of breast surgery techniques. In this title, esteemed international contributors offer you expert step-by-step advice on a wide array of surgical procedures, including the newest ablative and reconstructive approaches, to help you expand your repertoire and hone your operative skills. Color surgical photos, biopsy specimens, and artists' renderings of key anatomy show you what to look for and how to proceed.
Cancer is clearly an age-related disease. Recent research in both aging and cancer has demonstrated the complex interaction between the two phenomena. This affects a wide spectrum of research and practice, anywhere from basic research to health care organization. Core examples of these close associations are addressed in this book. Starting with basic research, the first chapters cover cancer development, mTOR inhibition, senescent cells altering the tumor microenvironment, and immune senescence affecting cancer vaccine response. Taking into account the multidisciplinarity of geriatric oncology, several chapters focus on geriatric and oncologic aspects in patient assessment, treatment option...
This innovative, comprehensive book covers key elements of perioperative management of older patients, from preoperative evaluation to post-hospital care.
A state-of-the-art, multidisciplinary approach to cancer and aging With the majority of cancers occurring in individuals over the age of 65 against a backdrop of an expanding aging population, there is an urgent need to integrate the areas of clinical oncology and geriatric care. This timely work tackles these issues head-on, presenting a truly multidisciplinary and international perspective on cancer and aging from world-renowned experts in geriatrics, oncology, behavioral science, psychology, gerontology, and public health. Unlike other books on geriatric oncology that focus mainly on treatment, Cancer and Aging Handbook: Research and Practice examines all phases of the cancer care continu...
This textbook provides a comprehensive overview of the state of the art knowledge of breast cancer management for the modern breast surgeon. It covers all aspects of multidisciplinary care including primary breast and axillary surgery, reconstruction and oncoplastic techniques, external beam radiotherapy and newer techniques such as tomotherapy, intraoperative radiotherapy and brachytherapy. In addition, systemic therapies including chemotherapy, the latest biological targeted therapies and endocrine therapies are covered. Readers can find out about other important aspects of breast cancer such as genetics, screening, imaging and long-term health among others. Chapters take the reader throug...