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Metastasis is responsible for a large burden of morbidity and mortality among cancer patients, and currently few therapies specifically target metastatic disease. Further scientific dissection of the underlying pathways is required to pave the way for new therapeutic targets. This groundbreaking new text comprehensively covers the processes underlying cancer metastasis and the clinical treatment of metastatic disease. Whereas previous volumes have been compendia of laboratory research articles, the internationally renowned authors of this volume have summarized the state-of-the-art research in the metastasis field. A major section covers the cellular and molecular pathways of metastasis and experimental techniques and the systems and models applied in this field. Subsequently, the clinical aspects of the major cancer types are considered, focusing on disease-specific research and therapeutic approaches to metastatic disease. The focus is on novel pathophysiological insights and emerging therapies; future directions for research and unmet clinical needs are also discussed.
Philosophy of Social Science: A Contemporary Introduction examines perennial questions of philosophy through engaging the empirical study of society. Questions of normativity concern the place of values in social scientific inquiry. Questions of naturalism concern the relationship between the natural and the social sciences. And questions of reductionism ask how social institutions relate to the people who constitute them. This accessible text offers a comprehensive overview of debates in the field, with special attention to new research programs. Topics include the relationship of social policy to social science, interpretive research, cognitive and evolutionary explanations, intentional ac...
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