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Introduction to geologic fracture mechanics covering geologic structural discontinuities from theoretical and field-based perspectives.
There have been tremendous advances in our understanding of molecular and tumor biology during the past few years. In the field of cancer therapeutics, it is expected that cytotoxic drug approaches will be gradually replaced with treatments based on biological targeted approaches. Hopefully these new targeted therapies will significantly increase efficacy and lack the devastating and troublesome side effects elicited by cytotoxic chemotherapy. This volume is the first book to cover the general topic of targeted cancer therapy. It presents a range of targets such as tumor angiogenesis, cell cycle control and cell signalling, COX-2, apoptosis/cell survival, invasion and metastasis and approach...
Contents: V. Zingel, C. Leschke and W. Schunack: Developments in research on histamine (H1) receptor agonists / P.D. Hoeprich: Antifungal chemotherapy / G. de Stevens: The diversity of heterocyclic compounds and their biological activities / R.M. Schultz: Newer antifolate compounds in cancer therapy / P.K. Mehrotra, S. Batra and A.P. Bhadun: Non-steroidal agents for regulation of the menstrual cycle / A.K. Saxena and M. Saxena: Developments in anti-convulsant drugs
This is the definitive reference on disaster medicine, outlining areas of proficiency for health care professionals handling mass casualty crises.
Based on a series of lectures developed by noted furniture designer Richard Schultz, this brief, striking book lays out his design manifesto both challenging and adding to Louis Sullivan's credo "form follows function." From African stools carved from a single log to advanced techniques of laminating wood; from simple twisted wire chairs to complex wire furniture bending in three axes; and from basic stonework to iconic post-and-beam structures, the art of design evolves along with the available materials and techniques. Combining Zen wisdom, examples of classic furniture, and a lifetime of experience as a designer, Schultz explores how technology both limits and fosters innovative design. It is the author's hope that this book will encourage students, designers, and others to think about new materials and techniques so that they, too, will create iconic designs.
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