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The pteridines in their multitude of forms fulfill many roles in nature ranging from pigments to cofactors for numerous redox and one-carbon transfer reactions. This extraordinary diversity of function is unified by the unique chemistry of the pteridine heterocycle. The International Symposium on the Chemistry and Biology of Pteridines and Folates is a forum for presenting recent and exciting advances in this expanding field. In of ideas results that has often stimulated bringing together various disciplines, a synergy fresh approaches to major problems. The Tenth International Symposium held at Orange Beach, Alabama, March 21-23, 1993, proved no exception by providing new insights into fola...
Major nephrological and psychological organizations have, at best, set aside only small portions of their programs for papers or panels devoted to the psychological aspect of patients with end-stage renal disease. Thus, the increased need for information concerning the psychological aspects of end-stage renal disease has been met by occasional journal articles, professional peer discussions, small portions of national confer ences, and informal conversations and consultations with people with clinical and research experience in these areas. The First International Conference on Psychological Factors in Hemodialysis and Transplantation arose out of a need to have a forum in which the major pe...
Much of organic chemistry is based on the ability of suitably structured chemicals to bind together through the formation of covalent bonds. Biochemistry is replete with exam ples of enzymatically catalyzed reactions in which normal body constituents can be linked through covalent bonds during the process of intermediary metabolism. The finding that xenobiotic chemicals that enter the body from the environment, are metabolized to highly reactive species, and then covalently react with cellular macromolecules to induce toxic and carcinogenic effects was an observation that spawned the research featured in the Fifth International Symposium on Biological Reactive Intermediates (BRI V). The grou...
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