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Gene Therapy of Autoimmune Disease
Autoimmune diseases are diverse and responsible for considerable morbidity. Their etiology remains largely unknown, and current therapy with anti-inflammatory drugs is prone to adverse effects, and rarely curative. New therapies with anti-cytokine antibodies or receptors are promising, but require frequent administration of expensive protein drugs. Gene Therapy of Autoimmune Diseases comprehensively reviews research in gene therapy for autoimmune diseases with viral or non-viral vectors. Gene therapy offers the possibility of long-term, continuous delivery of a wide variety of immunosuppressive, anti-inflammatory, or tolerance-inducing agents. Moreover, highly specific genetically modified cells can be produced. This book discusses the most promising avenues in this exciting new field.
Gene Therapy for Autoimmune and Inflammatory Diseases
In this monograph about gene therapy of autoimmune and inflammatory d- orders we have gathered international experts and leaders from different fields to review the state of the art advances on topics ranging from disease entities to vectors and engineered cells. The different approaches described in each chapter take into consideration the biomedical knowledge of these diseases and address the complexities of delivering long-term genetic interventions. Gene therapy also serves as a testing ground for new therapeutic entities and helps provide proof of principle for their potential therapeutic role in animal models of disease. Scaling up from mice to men still remains an important h- dle not...
Cerebrospinal Fluid in Clinical Neurology
The cerebrospinal fluid (CSF) is an invaluable diagnostic tool in clinical neurology, not only in the evaluation of inflammatory, degenerative, and malignant diseases of the nervous system, but also in the diagnosis of all forms of cerebral and subarachnoidal bleedings. The CSF can be easily obtained by lumbar puncture and a set of basic analyses can be conducted using relatively simple laboratory methods. By combining different CSF parameters, a wide range of diagnostic entities can be identified. However, properly interpreting the test results requires a high level of expertise and cannot be achieved by just reporting on individual analytic values. This book covers essential aspects of cer...
Plasticity in Multiple Sclerosis: from molecular to system level, from adaptation to maladaptation
This research topic aims at providing a state of the art update on neuroplasticity in humans with multiple sclerosis. It summarizes advances in plasticity research as achieved by a variety of techniques, in the motor as well as visual and cognitive domain. We are confident that this collection of articles broadens the view across systems and techniques and widens our understanding of this exciting field of research.
Modern Analysis of Customer Surveys
Customer survey studies deals with customers, consumers and user satisfaction from a product or service. In practice, many of the customer surveys conducted by business and industry are analyzed in a very simple way, without using models or statistical methods. Typical reports include descriptive statistics and basic graphical displays. As demonstrated in this book, integrating such basic analysis with more advanced tools, provides insights on non-obvious patterns and important relationships between the survey variables. This knowledge can significantly affect the conclusions derived from a survey. Key features: Provides an integrated, case-studies based approach to analysing customer survey...
Spirits of Life and Perception
Does a plant shrink at night and swell in the day, like an animal breathing in and out? For a long time, the Galenic concept of spiritus provided a causal explanation for human and animal life and perception. Albert the Great (1200-1280), whose honorific acknowledges among other things his pioneering work on biology, extended the concept to plants. This is only one of the remarkable concepts studied in this book, the first comparative study of Albert's concept of spiritus. It unveils the Arabic roots of his early psychophysiology and the original developments found in his mature Aristotelian paraphrases.
Human Activity and Behavior Analysis
Human Activity and Behavior Analysis relates to the field of vision and sensor-based human action or activity and behavior analysis and recognition. The book includes a series of methodologies, surveys, relevant datasets, challenging applications, ideas, and future prospects. The book discusses topics such as action recognition, action understanding, gait analysis, gesture recognition, behavior analysis, emotion and affective computing, and related areas. This volume focuses on relevant activities in three main subject areas: Healthcare and Emotion, Mental Health, and Nurse Care Records. The editors are experts in these arenas and the contributing authors are drawn from high-impact research groups around the world. This book will be of great interest to academics, students, and professionals working and researching in the field of human activity and behavior analysis.
Tumor Necrosis Factor
Because tumor necrosis factor-a (TNF-a) plays a pivotal role in the regulation of homeostasis and inflammatory immune responses, it offers valuable research opportunities to develop new drugs for the treatment of a wide range of disorders, including cancer, septic shock, rheumatoid arthritis, and other inflammatory diseases. In Tumor Necrosis Factor: Methods and Protocols, well-versed experimentalists survey the basic and translational research being conducted in this field and describe in detail the methods they have developed for TNF production, characterization, mutagenesis, and detection in biological specimens. They also provide several in vitro assays and animal models for studying the...
