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Novel Aspects of Lipoprotein Metabolism with Focus on Systemic Inflammation
With cardiometabolic diseases still topping the list of mortality causes and in facing the obesity and diabetes epidemic, there remains a great need to better understand the pathophysiological derangements underlying these conditions. During the past years, it has become increasingly appreciated that low grade systemic inflammation is a common hallmark of cardiometabolic disorders—not only concerning diabetes and atherosclerotic cardiovascular disease but also involving non-alcoholic fatty liver disease. Recently developed high-throughput laboratory techniques for lipidomics and metabolomics have enabled researchers to discern novel crosstalk pathways between lipid phenotypes and enhanced chronic inflammation. With this Special Issue of the Journal of Clinical Medicine, entitled “Novel Aspects of Lipoprotein Metabolism with a Focus on Systemic Inflammation”, researchers were invited to submit original papers and reviews on various topics, in particular, at the interface of lipid metabolism and inflammation.
Lipids and the Kidney
During the past decade, experimental and clinical studies have suggested that dyslipidemia may be an important risk factor for the progression of renal disease. This volume explores in great detail recent advances in our understanding of the pathogenesis and treatment of this common complication of progressive renal injury. In the experimental investigations presented, emphasis is placed on specific disturbances of lipids that are seen in progressive renal disease including the effects of oxidatively modified lipoproteins and Lp(a) on various functions of the glomerular cells. Clinical studies have identified dyslipidemia as a risk factor for progressive renal disease in diabetes mellitus, v...
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Zellen · Leben · Relationomische Medizin
Der Makrokosmos, den wir als Kulturwesen ständig verändern, beeinflusst auch den Mikrokosmos unserer Zellen. Dies hat Konsequenzen nicht nur für unsere Ernährung, unseren Lebensstil und die Medizin, sondern auch für den Umgang mit unserer Umwelt und den Ressourcen. Und es hat Konsequenzen für die Regeln, die wir uns als freie Menschen auferlegen, um zu überleben. Aufgrund der herausragenden Bedeutung der Relationen werden in diesem Buch drei neue Begriffe vorgeschlagen: das Relationom beziehungsweise die Relationome, die Relationom-Forschung und die Relationomische Medizin. Denn alles ist miteinander verbunden. Wir leben in Beziehung zu allem, was da draußen und in uns ist, mittelbar und unmittelbar. Deshalb ist die Betrachtung von Relationomen des Makro- und Mikrokosmos fundamental in der Relationomischen Medizin. Die Relationomische Medizin ist eine praktische Wissenschaft, bei der die Relationome in Hinblick auf ihre Bedeutung für die Prävention, Entstehung und Heilung von Krankheiten im Fokus stehen.
High Density Lipoproteins
In this Handbook of Experimental Pharmacology on “High Density Lipoproteins – from biological understanding to clinical exploitation” contributing authors (members of COST Action BM0904/HDLnet) summarize in more than 20 chapters our current knowledge on the structure, function, metabolism and regulation of HDL in health and several diseases as well as the status of past and ongoing attempts of therapeutic exploitation. The book is of interest to researchers in academia and industry focusing on lipoprotein metabolism, cardiovascular diseases and immunology as well as clinical pharmacologists, cardiologists, diabetologists, nephrologists and other clinicians interested in metabolic or inflammatory diseases.
A Pinch of Salt
It is important to acknowledge how far research has come within the last few years and how salt has played a role in the SARS outbreak, the H1N1 virus outbreak, and now, COVID-19. Each new approach, study, trial, and prototype brings us a step closer to finding a treatment and cure for the global health crisis of the century. Salt and its extensive history, dating back to its discovery far earlier than any historical record, has proven its worth as an essential component in our world of food, disinfectants, and preservatives. Whole cities, towns, and civilizations were built based on the availability of salt, as it was considered to be a vital aspect of human life given its widely accessible and inexpensive nature. While this may seem absurd, it proves to us that salt and its multifaceted roles over decades and centuries have emerged to be effective.
