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Flavonoids in the Living System
The presence of contaminant flavonoids in vitamin C preparations from citrus fruits initially led Szent-Gyorgyi and his collaborators to suggest that a flavonoid compound, with biological activity for the prevention of capillary fragility, was vitamin P. Later re search, although not disproving biological activity, discontinued the use of the vitamin classification for these compounds. However, the ubiquitous distribution of flavonoids in living organisms, and the continued discovery of various activity in biological systems makes these compounds targets of wide ranging investigation. This volume is primarily based on a Symposium on Flavonoids and related com pounds held during the 212th Nat...
Chocolate as Medicine
The Mesoamerican population who lived near the indigenous cultivation sites of the "Chocolate Tree" (Theobromo cacao) had a multitude of documented applications of chocolate as medicine, ranging from alleviating fatigue to preventing heart ailments to treating snakebite. Until recently, these applications have received little sound scientific scrutiny. Rather, it has been the reputed health claims stemming from Europe and the United States which have attracted considerable biomedical attention. This book, for the first time, describes the centuries-long quest to uncover chocolate's potential health benefits. The authors explore variations in the types of evidence used to support chocolate's ...
Anticonvulsants
Medicinal Chemistry: A Series of Monographs, Volume 15: Anticonvulsants discusses the laboratory evaluation, drug disposition, clinical evaluation, and synthesis and design of anticonvulsant drugs. This book is organized into eight chapters. Chapters 1 and 2 provide an overview and neuropharmacological background of anticonvulsants. The laboratory evaluation of compounds is described in Chapter 3, while drug disposition is treated in Chapter 4. The chemistry and biological activities of the various classes of anticonvulsant compounds, such as cyclic ureides, benzopyrans, heterocyclic drugs, and noncyclic anticonvulsants are presented in Chapters 5 to 8. This volume is written specifically for medicinal chemists, biochemists, neurologists, and pharmacologists.
Aspartic Proteinases
The VIIth International Conference on Aspartic Proteinases was held in Banff, Alberta, Canada, from October 22 to 27, 1996. The venue was the Banff Centre in the Canadian Rockies, a setting well known worldwide for the scenic beauty and mountain grandeur. It was perhaps presumptuous of the organizers to call this the seventh Aspartic Proteinase Conference but it was felt that the meeting in 1982, organized by Tom Blundell and John Kay, was of an international stature and covered topics sufficiently broad to constitute a conference. Thus, there is a discontinuity in that the Gifu Conference organized by Prof. Kenji Takahashi was the fifth International Conference on Aspartic Proteinases. Officially, there has not been a sixth Conference and if there is confusion, it is the result of my desire to recognize the importance of the London meeting. Banffhosted 106 scientists from 14 different countries. There were 26 invited speak ers among the 44 oral presentations of the 7 main sessions. In addition, there were 53 con tributed poster presentations that spanned the whole range of interest in aspartic proteinases.
Ganglioside Function
The volume which is here presented reports all the lectures given at the International Satellite Meeting on Biochemical and Pharmacological Implications of Ganglioside Function held at Cor tona, Tuscany, Italy from 28 to 31 August, 1975. The Meeting was run just before the 5th International Congress of the International Society for Neurochemistry (Barcelona, 2-7 september, 1975) and was in fact organized on its frame. The general subject matter of gangliosides structure, biosyn thesis and degradation, of their functional role in neurochemistry, their pharmacological action and future potentialities, was deeply and throughly taken into consideration during the three-day Sympo sium, which was ...
Nutritional Improvement of Food and Feed Proteins
The nutritional quality of a protein depends on the proportion of its amino acids-especially the essential amino acids-their physio logical availability, and the specific requirements of the consumer. Availability varies and depends on protein source, interaction with other dietary components, and the consumer's age and physiological state. In many foods, especially those from plants, low levels of various essential amino acids limits their nutritive value. This is particularly important for cereals (which may be inadequate in the essential amino acids isoleucine, lysine, threonine, and tryto phan) and legumes (which are often poor sources of methionine). Moreover, these commodities are prin...
Immunologic Phylogeny
There are two now classic reasons for the widespread and con tinuing interest in the phylogeny of immune reactivities and structure. First is the fundamental concern of biologists with the evolution of defense mechanisms. We are eager to discover origins, mechanisms, and adaptive specializations of immunocompetence because the very existence of individuals and entire species is involved in a most essential way. Second is the strong biomedical interest in adaptive immune mechanisms to increase understanding of health and disease in man. If man and placental mammals represent the quin tessence of immunoresponsiveness with complex interdependent path ways, the less elaborate but fully functiona...
Lacrimal Gland, Tear Film, and Dry Eye Syndromes 2
Harvard Medical School, Boston, MA. Proceedings of the Second International Conference on the Lacrimal Gland, Tear Film, and Dry Eye Syndromes, held November 16-19, 1996, at the Southampton Princess Resort, Bermuda. DNLM: Lacrimal Apparatus--congresses.
