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Fast Facts: Gene Therapy
Gene therapy has emerged as a discipline in medicine that can provide treatments for diseases that have no other therapies available, save lives of patients for whom there is no other hope and replace suboptimal treatments with lasting cures. 'Fast Facts: Gene Therapy' provides an overview of the field, looking at the main vector systems used to transfer the therapeutic gene constructs, the molecular mechanisms and the history of gene therapy, as well as the safety and ethical considerations of this important advance. Multiple examples of diseases that are already successfully treated with gene therapy are given, with discussion of treatments that hold promise for the future. This book will be informative and of value to health professionals, researchers, students and anyone with an interest in this exciting and fast-moving area. Contents: • Principles of gene therapy • Gene therapy techniques • Ethical and safety considerations • Gene therapies with proven clinical efficacy • Genome editing • Research directions – the next wave of treatments
A Guide to Human Gene Therapy
1. Non-viral gene therapy / Sean M. Sullivan -- 2. Adenoviral vectors / Stuart A. Nicklin and Andrew H. Baker -- 3. Retroviral vectors and integration analysis / Cynthia C. Bartholomae [und weitere] -- 4. Lentiviral vectors / Janka Matrai, Marinee K.L. Chuah and Thierry VandenDriessche -- 5. Herpes simplex virus vectors / William F. Goins [und weitere] -- 6. Adeno-Associated Viral (AAV) vectors / Nicholas Muzyczka -- 7. Regulatory RNA in gene therapy / Alfred. S. Lewin -- 8. DNA integrating vectors (Transposon, Integrase) / Lauren E. Woodard and Michele P. Calos -- 9. Homologous recombination and targeted gene modification for gene therapy / Matthew Porteus -- 10. Gene switches for pre-clini...
Gene Therapy Immunology
Summarises and reviews the important field of genetic therapy with respect to the latest immunological advances in the lab and clinic Unique treatment of immunology and immunotherapy in gene - approached from a vector and target organ point of view rather than from the perspective a specific diseases Broad appeal - applicable for immunology and genetics / gene therapy, recombinant DNA studies, transplantation, virology, cancer research and tumor research
Optimal Control
This book may serve as a basis for students and teachers. The text should provide the reader with a quick overview of the basics for Optimal Control and the link with some important conceptes of applied mathematical, where an agent controls underlying dynamics to find the strategy optimizing some quantity. There are broad applications for optimal control across the natural and social sciences, and the finale to this text is an invitation to read current research on one such application. The balance of the text will prepare the reader to gain a solid understanding of the current research they read.
Mesh Dependence in PDE-Constrained Optimisation
This book provides an introduction to PDE-constrained optimisation using finite elements and the adjoint approach. The practical impact of the mathematical insights presented here are demonstrated using the realistic scenario of the optimal placement of marine power turbines, thereby illustrating the real-world relevance of best-practice Hilbert space aware approaches to PDE-constrained optimisation problems. Many optimisation problems that arise in a real-world context are constrained by partial differential equations (PDEs). That is, the system whose configuration is to be optimised follows physical laws given by PDEs. This book describes general Hilbert space formulations of optimisation ...
Optimization and Control for Partial Differential Equations
This book highlights new developments in the wide and growing field of partial differential equations (PDE)-constrained optimization. Optimization problems where the dynamics evolve according to a system of PDEs arise in science, engineering, and economic applications and they can take the form of inverse problems, optimal control problems or optimal design problems. This book covers new theoretical, computational as well as implementation aspects for PDE-constrained optimization problems under uncertainty, in shape optimization, and in feedback control, and it illustrates the new developments on representative problems from a variety of applications.
Trends in PDE Constrained Optimization
Optimization problems subject to constraints governed by partial differential equations (PDEs) are among the most challenging problems in the context of industrial, economical and medical applications. Almost the entire range of problems in this field of research was studied and further explored as part of the Deutsche Forschungsgemeinschaft (DFG) priority program 1253 on “Optimization with Partial Differential Equations” from 2006 to 2013. The investigations were motivated by the fascinating potential applications and challenging mathematical problems that arise in the field of PDE constrained optimization. New analytic and algorithmic paradigms have been developed, implemented and vali...
Advances in Structural and Multidisciplinary Optimization
The volume includes papers from the WSCMO conference in Braunschweig 2017 presenting research of all aspects of the optimal design of structures as well as multidisciplinary design optimization where the involved disciplines deal with the analysis of solids, fluids or other field problems. Also presented are practical applications of optimization methods and the corresponding software development in all branches of technology.
Large-Scale Scientific Computing
This book constitutes the thoroughly refereed post-conference proceedings of the 8th International Conference on Large-Scale Scientific Computations, LSSC 2011, held in Sozopol, Bulgaria, in June 2011. The 74 revised full papers presented together with 3 plenary and invited papers were carefully reviewed and selected from numerous submissions. The papers are organized in topical sections on robust multigrid, multilevel and multiscale, deterministic and stochastic methods for modeling highly heterogeneous media, advanced methods for transport, control and uncertain systems, applications of metaheuristics to large-scale problems, environmental modelling, large scale computing on many-core architectures, multiscale industrial, enviromental and biomedical problems, efficient algorithms of computational geometry, high performance Monte Carlo simulations, voxel based computations and contributed papers.
