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Optimal Control
This book may serve as a basis for students and teachers. The text should provide the reader with a quick overview of the basics for Optimal Control and the link with some important conceptes of applied mathematical, where an agent controls underlying dynamics to find the strategy optimizing some quantity. There are broad applications for optimal control across the natural and social sciences, and the finale to this text is an invitation to read current research on one such application. The balance of the text will prepare the reader to gain a solid understanding of the current research they read.
Large-Scale Scientific Computing
This book constitutes the thoroughly refereed post-conference proceedings of the 8th International Conference on Large-Scale Scientific Computations, LSSC 2011, held in Sozopol, Bulgaria, in June 2011. The 74 revised full papers presented together with 3 plenary and invited papers were carefully reviewed and selected from numerous submissions. The papers are organized in topical sections on robust multigrid, multilevel and multiscale, deterministic and stochastic methods for modeling highly heterogeneous media, advanced methods for transport, control and uncertain systems, applications of metaheuristics to large-scale problems, environmental modelling, large scale computing on many-core architectures, multiscale industrial, enviromental and biomedical problems, efficient algorithms of computational geometry, high performance Monte Carlo simulations, voxel based computations and contributed papers.
A Guide to Human Gene Therapy
1. Non-viral gene therapy / Sean M. Sullivan -- 2. Adenoviral vectors / Stuart A. Nicklin and Andrew H. Baker -- 3. Retroviral vectors and integration analysis / Cynthia C. Bartholomae [und weitere] -- 4. Lentiviral vectors / Janka Matrai, Marinee K.L. Chuah and Thierry VandenDriessche -- 5. Herpes simplex virus vectors / William F. Goins [und weitere] -- 6. Adeno-Associated Viral (AAV) vectors / Nicholas Muzyczka -- 7. Regulatory RNA in gene therapy / Alfred. S. Lewin -- 8. DNA integrating vectors (Transposon, Integrase) / Lauren E. Woodard and Michele P. Calos -- 9. Homologous recombination and targeted gene modification for gene therapy / Matthew Porteus -- 10. Gene switches for pre-clini...
Mesh Dependence in PDE-Constrained Optimisation
This book provides an introduction to PDE-constrained optimisation using finite elements and the adjoint approach. The practical impact of the mathematical insights presented here are demonstrated using the realistic scenario of the optimal placement of marine power turbines, thereby illustrating the real-world relevance of best-practice Hilbert space aware approaches to PDE-constrained optimisation problems. Many optimisation problems that arise in a real-world context are constrained by partial differential equations (PDEs). That is, the system whose configuration is to be optimised follows physical laws given by PDEs. This book describes general Hilbert space formulations of optimisation ...
Trends in PDE Constrained Optimization
Optimization problems subject to constraints governed by partial differential equations (PDEs) are among the most challenging problems in the context of industrial, economical and medical applications. Almost the entire range of problems in this field of research was studied and further explored as part of the Deutsche Forschungsgemeinschaft (DFG) priority program 1253 on “Optimization with Partial Differential Equations” from 2006 to 2013. The investigations were motivated by the fascinating potential applications and challenging mathematical problems that arise in the field of PDE constrained optimization. New analytic and algorithmic paradigms have been developed, implemented and vali...
Mathematical Foundations of Big Data Analytics
In this textbook, basic mathematical models used in Big Data Analytics are presented and application-oriented references to relevant practical issues are made. Necessary mathematical tools are examined and applied to current problems of data analysis, such as brand loyalty, portfolio selection, credit investigation, quality control, product clustering, asset pricing etc. – mainly in an economic context. In addition, we discuss interdisciplinary applications to biology, linguistics, sociology, electrical engineering, computer science and artificial intelligence. For the models, we make use of a wide range of mathematics – from basic disciplines of numerical linear algebra, statistics and ...
Advances in Structural and Multidisciplinary Optimization
The volume includes papers from the WSCMO conference in Braunschweig 2017 presenting research of all aspects of the optimal design of structures as well as multidisciplinary design optimization where the involved disciplines deal with the analysis of solids, fluids or other field problems. Also presented are practical applications of optimization methods and the corresponding software development in all branches of technology.
Thermo-energetic Design of Machine Tools
The approach to the solution within the CRC/TR 96 financed by the German Research Foundation DFG aims at measures that will allow manufacturing accuracy to be maintained under thermally unstable conditions with increased productivity, without an additional demand for energy for tempering. The challenge of research in the CRC/TR 96 derives from the attempt to satisfy the conflicting goals of reducing energy consumption and increasing accuracy and productivity in machining. In the current research performed in 19 subprojects within the scope of the CRC/TR 96, correction and compensation solutions that influence the thermo-elastic machine tool behaviour efficiently and are oriented along the th...
