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This book contains the summaries of the "Innovation in Pharmacy: Advances and Perspectives" that took place in Salamanca (Spain) in September 2018. The early science of chemistry and microbiology were the source of most drugs until the revolution of genetic engineering in the mid 1970s. Then biotechnology made available novel protein agents such as interferons, blood factors and monoclonal antibodies that have changed the modern pharmacy. Over the past year, a new pharmacy of oligonucleotides has emerged from the science of gene expression such as RNA splicing and RNA interference. The ability to design therapeutic agents from genomic sequences will transform treatment for many diseases. The...
Despite accurate preoperative assessment and adequate preparation, unexpected, and sometimes disastrous, situations can occur during vascular and endovascular procedures. This latest book in the European Vascular Course series provides vascular and endovascular surgeons with the skills and techniques needed to solve these unforeseen intraoperative complications. It includes thirteen chapters on aortic neck problems during open and endovascular repair, ruptured clamp sites, ureteral lesions, unintentional covering of side branches, totally calcified aorta and embolization. Accidental conditions during carotid and lower limb revascularization are also covered in six chapters and additional challenges are described in another seven chapters.
A political biography, history of of a revolutionary era, and nonstop adventure story across three continents.
This open access book explores the history of risk management in medieval and early modern European maritime business, focusing particularly on 'General Average' – a mechanism by which extraordinary expenses regarding ship or cargo, incurred during a voyage to save the venture, are shared between all participants to protect equity. This volume traces the history of this risk management tool from its origins in the pre-Roman Mediterranean through to its use in the shipping sector today. Contributions range from the Islamic Mediterranean to the Low Countries, and taken together, provide a wide-ranging analysis of social, cultural, and political aspects of pre-modern maritime commerce in Europe.