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Hypertension and Stroke
This timely volume addresses the intimate pathophysiologic relationship between hypertension and cardiovascular disease. Hypertension is one of the most important global public health challenges, and its relationship to stroke and other catastrophic cerebrovascular diseases is an area of growing understanding. In this outstanding book, the editors and authors clearly and concisely synthesize our developing knowledge and place epidemiologic and physiologic information into a practical clinical context. Comprehensive chapters present the evidence supporting strategies for stroke prevention and care, including blood pressure lowering therapies, anti-coagulation, and management of other cerebrov...
Lower Extremity Arterial Disease
A comprehensive review the state-of-the-art in atherosclerosis of the arteries of the legs and feet. The authors discuss in detail the primary symptom-claudication-an intermittent pain in the leg or foot while walking, its predisposing factors, the current diagnostic methodologies, the impressive advances in the therapeutic armamentarium, and the need to screen for co-existing coronary artery disease. Additional chapters describe cutting-edge noninvasive angiography and vascular flow studies, specific drug therapy for claudication, regression of atherosclerosis therapy, gene therapy, and drug eluting stents for peripheral arterial disease. The authors also examine the epidemiology of LEAD, the effects of smoking and effective smoking cessation programs, its pathogenesis and its association with lipid abnormalities and hypertension, aggressive risk factor modification, and the need to measure the ankle brachial index of every patient over 45.
Clinical Pediatric Nephrology, Second Edition
Revised in line with feedback from users of the first edition, this practical clinical resource boasts a worldwide array of contributors, including the most prominent pediatric nephrologists in the US. Excellently illustrated with photomicrographs and clinical diagrams supporting the chapters, Clinical Pediatric Nephrology features expanded case histories relating to the discussion and management of renal disease – thus ensuring that this is a highly useful reference tool for nephrologists and house officers in practice, as well as nephrology fellows in training.
Guide to Paediatric Drug Development and Clinical Research
Children in the developed world have never enjoyed better medical care: mortality has decreased and many fatal diseases of the past can today be prevented or even cured. However, the current practice of pharmacotherapy in children does not reflect existing scientific knowledge and has come under scrutiny by paediatricians, pharmacists and regulatory authorities. In order to advance the development of medicines tailored to paediatric needs, US and EU legislators have taken action, and the WHO has initiated a global paediatric campaign. This book gives an overview over the worldwide activities that increasingly include children in the development of new medicines. Triggered by both a better un...
Pediatric Nephrology
Pediatric Nephrology is the premier comprehensive reference on congenital and acquired kidney diseases and their therapies in children. Section One opens with an overview of the anatomy, physiology, and biology of the pediatric kidney, critical to understanding disease. Section Two covers the evaluation, diagnosis, and therapy of specific kidney disorders. The book has an international focus, and is well knows for describing how research developments are applied in the clinical arena.
Blood Pressure Monitoring in Cardiovascular Medicine and Therapeutics
This is a newly updated second edition of Blood Pressure Monitoring in Cardiovascular Medicine and Therapeutics. William B. White, MD, and a panel of highly experienced clinicians critically review every aspect of out-of-office evaluation of blood pressure. The world-class opinion leaders writing here describe the significant advances in our understanding of the circadian pathophysiology of cardiovascular disorders.
Hypertension in the Elderly
A comprehensive review of all aspects of hypertension in the elderly using the most current clinical data. Topics range from basic concepts, epidemiology and trials, and evaluation and management, to pharmacologic treatment, special populations, and adherence, all presented with an emphasis on the optimal management of patients. The authors examine in detail the mechanisms of hypertension in the elderly, the lifestyle trials and outcomes trials that were conducted in older persons, as well as the problems of clinical evaluation, secondary hypertension, adherence, and target organ damage. Extensive discussions of pharmacologic therapy detail the role of all the major drug classes.
Safe and Effective Medicines for Children
The Best Pharmaceuticals for Children Act (BPCA) and the Pediatric Research Equity Act (PREA) were designed to encourage more pediatric studies of drugs used for children. The FDA asked the IOM to review aspects of pediatric studies and changes in product labeling that resulted from BPCA and PREA and their predecessor policies, as well as assess the incentives for pediatric studies of biologics and the extent to which biologics have been studied in children. The IOM committee concludes that these policies have helped provide clinicians who care for children with better information about the efficacy, safety, and appropriate prescribing of drugs. The IOM suggests that more can be done to increase knowledge about drugs used by children and thereby improve the clinical care, health, and well-being of the nation's children.
Pediatric Hypertension
For the past 17 years, Pediatric Hypertension has served as the definitive reference text on hypertension in children and adolescents. Each edition has incorporated the latest research on the pathophysiology, clinical significance and management of hypertension in the young, and has incorporated the most current consensus guidelines on diagnosis and management. The years since publication of the fourth edition have seen further advances in the field that merit publication of an updated, expanded text, including: Analysis of the implications of updated hypertension guidelines on identification of youth at highest cardiovascular risk Additional data on the proximate effects of high blood press...
