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Oxidative Metabolism in Inflammation
Mitochondrial activity is involved in different functions such as cell proliferation, metabolism, Adenosine triphosphate (ATP) generation, and cell death. Particularly, mitochondria play a major role in inflammatory signaling. They regulate the activation, differentiation, and survival of macrophages, while changes in oxidative metabolism alter polarization. Mitochondria are the main source of free radicals, and macrophages increase their oxidative stress levels when they are active. The enhancement of free radicals generation in the mitochondria can damage healthy cells, leading to inflammation. Thus, several diseases associated with an increase in mitochondrial oxidative stress can be asso...
The Metabolic Approach to Cancer
The Optimal Terrain Ten Protocol to Reboot Cellular Health Since the beginning of the twentieth century, cancer rates have increased exponentially--now affecting almost 50 percent of the American population. Conventional treatment continues to rely on chemotherapy, surgery, and radiation to attack cancer cells. Yet research has repeatedly shown that 95 percent of cancer cases are directly linked to diet and lifestyle. The Metabolic Approach to Cancer is the book we have been waiting for--it offers an innovative, metabolic-focused nutrition protocol that actually works. Naturopathic, integrative oncologist and cancer survivor Dr. Nasha Winters and nutrition therapist Jess Higgins Kelley have ...
Cancer and the New Biology of Water
"When President Nixon launched the War on Cancer with the signing of the National Cancer Act of 1971 and the allocation of billions of research dollars, it was amidst a flurry of promises that a cure was within reach. The research establishment was trumpeting the discovery of oncogenes, the genes that supposedly cause cancer. As soon as we identified them and treated cancer patients accordingly, cancer would become a thing of the past. Fifty years later it's clear that the War on Cancer has failed--despite what the cancer industry wants us to believe. New diagnoses have continued to climb; one in three people in the United States can now expect to battle cancer during their lifetime. For the...
The Aging Immune System and Health
The world population presents an increased percentage of individuals over 65 years old and the fastest growing subgroup is over 85 years old. The increase in life expectancy observed in the last century has not been synonymous with extra years lived in good health (disability-free years). Population studies have shown that as individuals age, they can present a great heterogeneity of ability and health. Therefore, aging has been associated for some individuals with disabilities and hospitalizations. Deaths related to infectious pathogens are increased in the aging population mainly due to pneumonia and influenza whereas Cytomegalovirus, Epstein-Barr virus, among other viruses seem to contrib...
Advancement of Melatonin Research in Plants
Melatonin (N-acetyl-5-methoxytryptamine) is a widely studied biomolecule, and its function has been investigated in bacteria, mammals, birds, amphibians, reptiles, fish and plants. Melatonin research in plants the last five years has attained an exponential growth phase and the number of publications related to phytomelatonin has significantly increased in present times. All this research is directed towards establishing multifarious roles of melatonin in plants, including the promotion of seed germination and seedling growth, influencing plant development and senescence, alteration of flowering and fruiting time and grain yield, modulating circadian rhythms, improving resistance against bio...
AACR 2022 Proceedings: Part B April 11-13
The AACR Annual Meeting is the focal point of the cancer research community, where scientists, clinicians, other health care professionals, survivors, patients, and advocates gather to share the latest advances in cancer science and medicine. From population science and prevention; to cancer biology, translational, and clinical studies; to survivorship and advocacy; the AACR Annual Meeting highlights the work of the best minds in cancer research from institutions all over the world.
What's New in Endocrinology? (Vol II)
This special edition aims to highlight recent breakthroughs or advances, new technologies, or challenges in the field of endocrinology. We, together with the leadership team of Specialty Chief Editors, have identified multiple areas of endocrinology where new discoveries were made recently which have led to new questions and challenges for the future. With this special collection, we hope to further explore the frontiers of endocrinology within and across specialties of endocrinology.
Developments in Tryptophan and Serotonin Metabolism
This volume contains the proceedings of the Tenth International Meeting of the International Study Group for Tryptophan Research (ISTR V), held at the University of Padova, Padova, Italy, from 25-29 June, 2002 under the auspices of the Ministry of Education, University and Research (MIUR) in Roma, the University of Padova, the Italian Chemical Society - Division of Pharmaceutical Chemistry, the Veneto Region and the City of Padova. The meeting was organized to cover the recent developments in the field of tryptophan research. Weare very honoured that so many speakers accepted our invitation to give plenary lectures which, with the other communications, demonstrated the high scientific value of the Meeting. The publications in this volume are subdivided into nine main chapters, and cover all the major aspects in immunology, neurobiology, psychiatry, pathology, clinics, metabolism, enzymology, pharmacology, toxicology, melatonin, exercise and analytical chemistry. The volume includes the contributions of 325 scientists from 24 countries, and the Musajo Memorial Lecture delivered by Prof. Osamu Hayaishi during the Opening Ceremony.
A Little Respect?
Discrimination against the LGBT+ community persists across Europe. Education is not immune to this: Young people across the continent continue to experience homophobic and transphobic behaviour in schools. This publication provides education practitioners and policy makers with historical perspectives, trends in educational practice, and reflections on desiderata for the future. This publication was developed as part of the All Inc! project, an ERASMUS+ KA2 partnership (2020-2023) funded by the European Commission and implemented by 16 educational institutions in Belgium, Germany, Greece, Hungary, the Netherlands, Poland, the United Kingdom, and Spain. The project's core aim is to encourage awareness, understanding, and inclusion of the LGBT+ community within and beyond the school gates as well as to reflect on what is needed in the future for an educational approach that is fit for purpose in contemporary society.
Neuroprotective Agents
The sixth in this series of Annals volumes brings together clinical and basic science researchers from many countries and disciplines in a common forum to address various approaches to neuroprotection. Topics covered include the following: clinical trials; clinical application of neuroprotective approaches; NMDA receptors as mediators of neurotoxicity and neuroprotection; models, mediators, and mechanisms of neurotoxicity and neuroprotection; dietary supplements as neuroprotectants; oxidative stress and approaches to neuroprotection; mitochondria as a target of neurotoxicity and neuroprotection; and genomic approaches. The 35 papers and 10 posters are taken from the Sixth International Conference on Neuroprotective Agents, held in September 2002 in South Carolina.
