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Engineering the Plant Factory for the Production of Biologics and Small-Molecule Medicines
Plant gene transfer achieved in the early ‘80s paved the way for the exploitation of the potential of gene engineering to add novel agronomic traits and/or to design plants as factories for high added value molecules. For this latter area of research, the term "Molecular Farming" was coined in reference to agricultural applications in that major crops like maize and tobacco were originally used basically for pharma applications. The concept of the “green biofactory” implies different advantages over the typical cell factories based on animal cell or microbial cultures already when considering the investment and managing costs of fermenters. Although yield, stability, and quality of the...
We Are Cuba!
The extraordinary account of the Cuban people’s struggle for survival in a post-Soviet world In the aftermath of the fall of the Soviet Union, Cuba faced the start of a crisis that decimated its economy. Helen Yaffe examines the astonishing developments that took place during and beyond this period. Drawing on archival research and interviews with Cuban leaders, thinkers, and activists, this book tells for the first time the remarkable story of how Cuba survived while the rest of the Soviet bloc crumbled. Yaffe shows how Cuba has been gradually introducing select market reforms. While the government claims that these are necessary to sustain its socialist system, many others believe they herald a return to capitalism. Examining key domestic initiatives including the creation of one of the world’s leading biotechnological industries, its energy revolution, and medical internationalism alongside recent economic reforms, Yaffe shows why the revolution will continue post-Castro. This is a fresh, compelling account of Cuba’s socialist revolution and the challenges it faces today.
Defence Against Bioterrorism
This volume is based on a multidisciplinary approach towards biological and chemical threats that can, and have been previously used in bioterrorism attacks around the globe. Current knowledge and evidence-based principles from the fields of synthetic biology, microbiology, plant biology, chemistry, food science, forensics, tactics, infective medicine, psychology and others are compiled to address numerous aspects and the complexity of bioterrorism attacks. The main focus is on biological threats, especially in the context of synthetic biology and its emerging findings that can be observed as possible threat and tool. The book examines microorganisms and their possible use in forensics, i.e....
Intracellular Antibodies
Recent advances in the field of recombinant antibodies have permitted the manipulation of genes encoding specific antibodies, thus allowing their ectopic expression in a wide variety of non-lymphoid cells. This volume describes how the ectopic expression of antibodies, as secreted or as intracellularly retargeted molecules, can be exploited to block biological functions or to confer new phenotypic traits (e.g. resistance to a virus). This is the first book describing this emerging technology, which is receiving increasing attention for application in many different fields and biological systems - from human gene therapy to plant biotechnology.
Antibody Engineering
In presenting a practical overview of the engineering of recombinant human or mouse monoclonal antibodies, the book incisively addresses essential topics such as antibody structure relevant to engineering, recombinatorial cDNA libraries, phage display, synthetic and humanized antibodies, engineering of affinity and biological effector functions, and plant, mammalian, and bacterial expression vectors and hosts. Antibody Engineering, Second Edition - written by leading experts and now thoroughly updated - is a unique resource for current information on the subject.
Subalternity vs. Hegemony, Cuba's Outstanding Achievements in Science and Biotechnology, 1959-2014
The present book introduces an original (new) perspective on Cuba. This book revisits Cuba's choice, after the 1959 revolution, to develop an advanced healthcare and scientific system. It also introduces new aspects of the problem development/underdevelopment. From the start, every effort of the Cuban leadership and scientific community was driven by the primary purpose of meeting the country’s basic economic and social needs. Immediate key measures taken after the revolution included free education up to higher levels and free health services. In only a couple of decades Third World diseases were defeated and a First World health profile was achieved. In the sciences, support and collabor...
Nanoparticles in Cancer Theranostics
This book comprehensively reviews the application of nanoparticles in cancer diagnosis and treatment. The introductory section provides a fundamental understanding of cancer biology, its global incidence and prevalence, and the intricate nano–bio interactions at the cellular level. The subsequent section discusses the pivotal role of nanoparticles in precise cancer detection, enhancing cancer imaging and serving as contrast agents for accurate diagnosis. It also presents cutting-edge nanotechnology-based methods for detecting HTLV-1 retroviruses. The following section covers the utilization of lipid-based nanoparticles, monoclonal antibodies, and advanced nanotherapeutics for targeted cancer treatments. This book is a useful resource for researchers, clinicians, and students in the fields of oncology and nanotechnology.
Annual Report
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History of Technology Volume 34
Despite having undergone major advances in recent years, the history of technology in Latin America is still an understudied topic. This is the first English-language volume to bring together a variety of critical perspectives on the history of technology in Latin America from the early-19th century through to the present day. This special issue, assembled by guest editor David Pretel, brings together a range of experts to explore a plethora of topics in Latin America's technological history. Papers include a study of rural telephony in in 20th-century Latin America; the rise of the 'Techno-class' in modern Brazil; an analysis of the rise and fall of three Caribbean commodities; the history of educational technology in Latin America, and science and technology in Cold War Chile. Special Issue: Technology in Latin American History Edited by David Pretel (Colegio de Mexico, Mexico) and Helge Wendt (Max Plank Institute for the History of Science, Germany)
