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The Bacteria: A Treatise on Structure and Function, Volume V: Heredity explores the role of bacterial genetics in heredity. The book includes chapters on genetic fine structure, genetic replication, and gene-enzyme relationships, along with gene transduction, bacterial episomes, and genetic recombination. This volume is organized into 10 chapters and begins with an overview of conjugation as a mechanism of genetic exchange in bacterial species such as Escherichia coli, Salmonella typhosa, Pseudomonas aeruginosa, Vibrio cholera, and Serratia marcescens. The book then discusses transduction, its uses and evolutionary implications, and the nature of the transducing particle as well as the trans...
Presenting all preclinical and clinical information available on genetically engineered toxins, this unique, single-source reference provides the most up-to-date methods and practical examples for conducting clinical studies in toxin molecular biology.;Reviewing difficult problems and their solutions, Genetically Engineered Toxins discusses techniques for clo;ning, expressing, and purifying recombinant toxins and genetically modified recombinant toxins; documents structure-function relationships in toxins, including comparative information; supplies theory and illustrations of chimeric toxins; delineates the preclinical assessments of new reagents; and summarizes approaches to drug design.;With over 1100 literature citations, Genetically Engineered Toxins is an invaluable resource for biochemists, molecular biologists, biotechnologists, pharmacologists, toxicologists, X-ray crystallographers, enzymologists, oncologists, hematologists, immunologists, rheumatologists, botanists, and graduate-level students in molecular biology, biotechnology, and clinical oncology courses.
A compelling analysis of nearly seven decades of antibiotic reform, framing our current efforts to stave off a post-antibiotic era. Winner of the CHOICE Outstanding Academic Title of the Choice ACRL In The Antibiotic Era, physician-historian Scott H. Podolsky narrates the far-reaching history of antibiotics, focusing particularly on reform efforts that attempted to fundamentally change how antibiotics are developed and prescribed. This sweeping chronicle reveals the struggles faced by crusading reformers from the 1940s onward as they advocated for a rational therapeutics at the crowded intersection of bugs and drugs, patients and doctors, industry and medical academia, and government and the...
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Documents relating to "NIH guidelines for research involving recombinant DNA molecules," Feb. 1975/June 1976- .