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Metabolic Profiling: Its Role in Biomarker Discovery and Gene Function Analysis
It is evident that biochemical control is not strictly hierarchical and that intermediary metabolism can contribute to control of regulatory pathways. Metabolic studies are therefore increasingly important in gene function analyses, and an increased interest in metabolites as biomarkers for disease progression or response to therapeutic intervention is also evident in the pharmaceutical industry. This book offers guidelines to currently available technology and bioinformatics and database strategies now being developed. Evidence is presented that metabolic profiling is a valuable addition to genomics and proteomics strategies devoted to drug discovery and development, and that metabolic profiling offers numerous advantages.
Metabolome Analyses:
Metabolome analysis is now recognized as a crucial component of functional genomic and systems biology investigations. Innovative approaches to the study of metabolic regulation in microbial, plant and animal systems are increasingly facilitating the emergence of systems approaches in biology. This book highlights analytical and bioinformatics strategies now available for investigating metabolic networks in microbial, plant and animal systems. The contributing authors are world leaders in this field and they present an unambiguous case for pursuing metabolome analysis as a means to attain a systems level understanding of complex biological systems.
Annual Review Of Plant Pathology
Plant Pathology has an important role to play in devising strategies suitable for sustainable agriculture. Some of the important steps to be taken by plant pathologists include the development of eco-friendly mechanisms of disease control through the use of biological resources, enhancing the resistant mechanisms of the plant through molecular means as well as studies on the interactions of biotic and abiotic stressors. The diversity of Agriculturally Important Microorganisms is far more than what we have found out till date and the function of these important microbes in agro-ecosystems is also equally diverse. The ability of plant growth promoting rhizobacteria, actinomycetes, plant growth...
Rapid Methods for Analysis of Biological Materials in the Environment
Contrary to common belief, infectious diseases are not as well under control as we would like. We are now at a crossroads regarding the impact of the environment on infectious diseases. Renewed interest in biological weapons and the emergence of new pathogens, coupled with a better understanding of the impact of infectious agents on other conventional diseases, has led us to realise that we can no longer remain complacent about the impact of infectious agents on human, animal and crop health. The present book first discusses current and emerging military and civilian policies on the environment. In addition, the impact of environmental biology on the future of space exploration is discussed, especially in reference to the Mars mission. There follows a discussion of the state of bacteria in the environment, with a presentation of current and emerging techniques of microbial investigation. Finally, two case studies are presented on the impact of these techniques on both political and environmental problems.
Infrared and Raman Spectroscopy in Forensic Science
This book will provide a survey of the major areas in which information derived from vibrational spectroscopy investigations and studies have contributed to the benefit of forensic science, either in a complementary or a unique way. This is highlighted by examples taken from real case studies and analyses of forensic relevance, which provide a focus for current and future applications and developments.
Kohonen Maps
The Self-Organizing Map, or Kohonen Map, is one of the most widely used neural network algorithms, with thousands of applications covered in the literature. It was one of the strong underlying factors in the popularity of neural networks starting in the early 80's. Currently this method has been included in a large number of commercial and public domain software packages. In this book, top experts on the SOM method take a look at the state of the art and the future of this computing paradigm. The 30 chapters of this book cover the current status of SOM theory, such as connections of SOM to clustering, classification, probabilistic models, and energy functions. Many applications of the SOM are given, with data mining and exploratory data analysis the central topic, applied to large databases of financial data, medical data, free-form text documents, digital images, speech, and process measurements. Biological models related to the SOM are also discussed.
Understanding Pathogen Behaviour
Pathogens respond dynamically to their environment. Understanding their behaviour is critical both because of evidence of increased resistance to established sanitation and preservation techniques, and because of the increased use of minimal processing technologies which are more vulnerable to the development of resistance. Understanding pathogen behaviour summarises the wealth of recent research and its implications for the food industry. After two introductory chapters on ways of analysing and modelling pathogens, Part one summarises current research on what determines pathogenicity, stress response, adaptation and resistance. Part two reviews the behaviour of particular pathogens, reviewi...
The Routledge Companion to Biology in Art and Architecture
The Routledge Companion to Biology in Art and Architecture collects thirty essays from a transdisciplinary array of experts on biology in art and architecture. The book presents a diversity of hybrid art-and-science thinking, revealing how science and culture are interwoven. The book situates bioart and bioarchitecture within an expanded field of biology in art, architecture, and design. It proposes an emergent field of biocreativity and outlines its historical and theoretical foundations from the perspective of artists, architects, designers, scientists, historians, and theoreticians. Includes over 150 black and white images.
Surface-Enhanced Raman Scattering
Almost 30 years after the first reports on surface-enhanced Raman signals, the phenomenon of surface-enhanced Raman scattering (SERS) is now well established. SERS gained particular interest after single-molecule Raman spectroscopy had been demonstrated. This book summarizes and discusses present theoretical approaches that explain the phenomenon of SERS and reports on new and exciting experiments and applications of the fascinating spectroscopic effect.
