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This textbook describes in detail the process of cancer metastasis from a single cell in the primary site through its arduous journey to the sentinel lymph node as the main gateway and beyond to distant sites. The most up-to-date knowledge on key topics in the molecular biology, diagnosis, and treatment of metastatic cancer is highlighted by a large panel of experts. The book begins with a comprehensive overview of the genetic and molecular mechanisms that promote or inhibit cancer metastasis through lymphatic pathways to lymph nodes or through vascular pathways to distant sites, providing the reader with an essential basic knowledge. This is followed by further details on the role of the im...
Polymers from natural sources are particularly useful as biomaterials and in regenerative medicine, given their similarity to the extracellular matrix and other polymers in the human body. This important book reviews the wealth of research on both tried and promising new natural-based biomedical polymers, together with their applications as implantable biomaterials, controlled-release carriers or scaffolds for tissue engineering.The first part of the book reviews the sources, processing and properties of natural-based polymers for biomedical applications. Part two describes how the surfaces of polymer-based biomaterials can be modified to improve their functionality. The third part of the bo...
Includes entries for maps and atlases.
This book describes a new pattern discovery approach based on the combination among rules between Perceptually Important Points (PIPs) and the Symbolic Aggregate approximation (SAX) representation optimized by Genetic Algorithm (GA). The proposed approach was tested with real data from S&P500 index and all the results obtained outperform the Buy&Hold strategy. Three different case studies are presented by the authors.
Materials Nanoarchitectonics: From Integrated Molecular Systems to Advanced Devices provides the latest information on the design and molecular manipulation of self-organized hierarchically structured systems using tailor-made nanoscale materials as structural and functional units. The book is organized into three main sections that focus on molecular design of building blocks and hybrid materials, formation of nanostructures, and applications and devices. Bringing together emerging materials, synthetic aspects, nanostructure strategies, and applications, the book aims to support further progress, by offering different perspectives and a strong interdisciplinary approach to this rapidly grow...
This proceedings contains papers presented at the 31st International Conference on Coastal Engineering, which has held in Hamburg, Germany (31 August - 5 September 2008). The proceeding is divided into five parts: Waves; Long Waves, Nearshore Currents, and Swash; Sediment Transport and Morphology; Coastal Management, Environment, and Risk; and Coastal Structures. The papers cover a broad range of topics including theory, numerical and physical modeling, field measurements, case studies, design, and management. Coastal Engineering 2008 provides coastal engineers, scientists, and planners, with state-of-the-art information on coastal engineering and coastal processes.
Chitosan in Biomedical Applications provides a thorough insight into the complete chitosan chemistry, collection, chemical modifications, characterization and applications of chitosan in biomedical applications and healthcare fields. Chitosan, a biopolymer of natural origin, has been explored for its variety of applications in biomedical research, medical diagnostic aids and material science. It is the second most abundant natural biopolymer after cellulose, and considered as an excellent excipient because of its non-toxic, stable, biodegradable properties. Several research innovations have been made on applications of chitosan in biomedical applications. The book explores key topics, such a...
Electrospinning is a versatile and effective technique widely used to manufacture nanofibrous structures from a diversity of materials (synthetic, natural or inorganic). The electrospun nanofibrous meshes' composition, morphology, porosity, and surface functionality support the development of advanced solutions for many biomedical applications. The Special Issue on “Electrospun Nanofibers for Biomedical Applications” assembles a set of original and highly-innovative contributions showcasing advanced devices and therapies based on or involving electrospun meshes. It comprises 13 original research papers covering topics that span from biomaterial scaffolds' structure and functionalization, nanocomposites, antibacterial nanofibrous systems, wound dressings, monitoring devices, electrical stimulation, bone tissue engineering to first-in-human clinical trials. This publication also includes four review papers focused on drug delivery and tissue engineering applications.
Due to the rapid advances over the past few years in the field of rapid prototyping, the crucial information for researchers in the field is scattered throughout numerous journals and thus not readily available. This carefully compiled collection of selected articles from the top Wiley-Blackwell journals on the topic of rapid prototyping provides the fundamentals necessary to comprehend current rapid prototyping technologies while also developing new ones. From the contents: * History of Rapid Prototyping in Medicine * Use of Imaging Modalities in Rapid Prototyping * Computer-Assisted Modeling of Tissues * Fused Deposition Modeling * Inkjet Printing * Stereolithography Apparatus and other Photopolymerization Techniques * Selective Laser Sintering * Materials Used in Rapid Prototyping * Future Developments With an extensive introduction and comments by the editors, this reference covers all relevant aspects so as to suit the audience's, bridging the gap between related disciplines.