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The Sun, the Solar Wind, and the Heliosphere
This volume represents the state of the art of the science covered by the International Association of Geomagnetism and Aeronomy (IAGA) Division IV: Solar Wind and Interplanetary Field. It contains a collection of contributions by top experts addressing and reviewing a variety of topics included under the umbrella of the division. It covers subjects that extend from the interior of the Sun to the heliopause, and from the study of physical processes in the Sun and the solar wind plasma to space weather forecasts. The book is organized in 6 parts: the solar interior, the solar atmosphere, the heliosphere, heliophysical processes, radio emissions, and coordinated science in the Sun-Earth system. In addition, we highlight some of the results presented during the IAGA Division IV symposia in the 11th Scientific Assembly of IAGA in Sopron, Hungary, on 23-30 August 2009, which was planned simultaneously with this book.
Innovations in Development, Translational Research and Manufacturing of CAR T cells
Immunotherapy with genetically engineered immune cell products is a transformative treatment modality with potential applications in various fields of medicine. A prime example is chimeric antigen receptor (CAR)-modified T cells in hematology and oncology, and the advent of CAR T cell therapies to treat infectious diseases, autoimmune disorders, and cardiovascular diseases. The medical need and demand from patients and caregivers require radical innovations to accelerate and improve pre-clinical development and clinical translation, provision of gene-transfer vectors, and immune cell product manufacturing as well as a critical reflection and discussion on ethical and socioeconomic aspects. T...
Planetary Atmospheric Electricity
This book is a comprehensive discussion of all issues related to atmospheric electricity in our solar system. It details atmospheric electricity on Earth and other planets and discusses the development of instruments used for observation.
Physics of the Sun and Its Atmosphere
This book presents a pedagogical, updated and modern view of the Sun from its interior to its exterior as well as the SunOCoEarth system. Written by eminent scientists in solar physics, the chapters deal with recent advances in solar physics, seismic Sun, solar magnetic field, waves and oscillations, spectroscopic diagnostics of solar plasmas, partially ionized lower atmosphere, coronal heating, coronal mass ejections, radio Sun, solar wind, and the SunOCoEarth system. Each chapter is fully illustrated and has a comprehensive reference list. The book covers all major topics in solar physics, and presents a rich menu to motivate graduate students who wish to pursue a solar physics research career.
Brief Therapy
A tapestry of rich and varied perspectives drawn from a remarkable event. The Brief Therapy Congress, sponsored by the Milton H. Erickson Foundation, brought together over 2200 therapists and an impressive faculty that included J. Barber, J. Bergman, S. Budman, G. Cecchin, N. Cummings, S. de Shazer, A. Ellis, M. Goulding, J. Gustafson, J. Haley, C. Lankton, S. Lankton, A. Lazarus, C. Madanes, W. O'Hanlon, P. Papp, E. Polster, E. Rossi, P. Sifneos, H. Strupp, P. Watzlawick, J. Weakland, M. Yapko and many more.
Nicholas Saved
Intelligent, pretty, and talented, nineteen-year-old Heather Keller appears to have a brilliant future ahead of her—until she is seduced into a Northern California cult. Heather travels the perilous borders between faith, mysticism, devotion, and fanaticism, while confronted with the psychological and political levers designed to tip spirituality into madness. Her mother, with the help of others in her small town, fights back to reclaim her daughter.
Physics of the Solar Corona
A thorough introduction to solar physics based on recent spacecraft observations. The author introduces the solar corona and sets it in the context of basic plasma physics before moving on to discuss plasma instabilities and plasma heating processes. The latest results on coronal heating and radiation are presented. Spectacular phenomena such as solar flares and coronal mass ejections are described in detail, together with their potential effects on the Earth.
Tailoring NK Cell Receptor-Ligand Interactions: an Art in Evolution, 2nd Edition
Recognition and killing of aberrant, infected or tumor targets by Natural Killer (NK) cells is mediated by positive signals transduced by activating receptors upon engagement of ligands on target surface. These stimulatory pathways are counterbalanced by inhibitory receptors that raise NK cell activation threshold through negative antagonist signals. While regulatory effects are necessary for physiologic control of autoimmune aggression, they may restrain the ability of NK cells to activate against disease. Overcoming this barrier to immune surveillance, multiple approaches to enhance NK-mediated responses are being investigated since two decades. Propelled by considerable advances in the un...
New Frontiers in Gene-Modified T Cell Technology
The development, clinical translation and recent efficacy of novel gene therapies targeting refractory malignancies has led to research that extends this technology to a variety of infectious and rheumatological diseases. Unlike conventional drugs or antibodies, T cells have the potential to target and exert effector function in response to disease in a dynamic manner, acting as a “living drug”. The most efficacious form of gene-modified T cells to date is the chimeric antigen receptor (CAR)-modified T cell, which redirects the specificity of T cells to an antigen expressed by tumor cells. Clinical experience with autologous CAR-T cells, primarily in hematologic malignancies, has underscored the feasibility and safety of the approach, while also demonstrating dramatic and sustained antitumor effects through mechanisms orthogonal to those of traditional anticancer therapies. However, several challenging obstacles must be surmounted in order to improve the broader efficacy of this approach.
