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Biophysical and Computational Tools in Drug Discovery
This book reviews recent physicochemical and biophysical techniques applied in drug discovery research, and it outlines the latest advances in computational drug design. Divided into 10 chapters, the book discusses about the role of structural biology in drug discovery, and offers useful application cases of several biophysical and computational methods, including time-resolved fluorometry (TRF) with Förster resonance energy transfer (FRET), X-Ray crystallography, nuclear magnetic resonance spectroscopy, mass spectroscopy, generative machine learning for inverse molecular design, quantum mechanics/molecular mechanics (QM/MM,ONIOM) and quantum molecular dynamics (QMT) methods. Particular attention is given to computational search techniques applied to peptide vaccines using novel mathematical descriptors and structure and ligand-based virtual screening techniques in drug discovery research. Given its scope, the book is a valuable resource for students, researchers and professionals from pharmaceutical industry interested in drug design and discovery.
DNA-targeting Molecules as Therapeutic Agents
There have been remarkable advances towards discovering agents that exhibit selectivity and sequence-specificity for DNA, as well as understanding the interactions that underlie its propensity to bind molecules. This progress has important applications in many areas of biotechnology and medicine, notably in cancer treatment as well as in future gene targeting therapies. The editor and contributing authors are leaders in their fields and provide useful perspectives from diverse and interdisciplinary backgrounds on the current status of this broad area. The role played by chemistry is a unifying theme. Early chapters cover methodologies to evaluate DNA-interactive agents and then the book provides examples of DNA-interactive molecules and technologies in development as therapeutic agents. DNA-binding metal complexes, peptide and polyamide–DNA interactions, and gene targeting tools are some of the most compelling topics treated in depth. This book will be a valuable resource for postgraduate students and researchers in chemical biology, biochemistry, structural biology and medicinal fields. It will also be of interest to supramolecular chemists and biophysicists.
Self-Cleaning Coatings
Provides an overview of the uses of self-cleaning coatings for materials and polymer scientists working in industry and academia.
Quadruplex Nucleic Acids
Gaining Insights into the Small Molecule Targeting of the G-Quadruplex in the c-MYC Promoter Using NMR and an Allele-Specific Transcriptional Assay, by Christine E. Kaiser, Vijay Gokhale, Danzhou Yang and Laurence H. Hurley.- Higher-Order Quadruplex Structures, by Luigi Petraccone.- Investigation of Quadruplex Structure Under Physiological Conditions Using In-Cell NMR, by Robert Hänsel, Silvie Foldynová-Trantírková, Volker Dötsch and Lukás Trantírek.- Circular Dichroism of Quadruplex Structures, by Antonio Randazzo, Gian Piero Spada and Mateus Webba da Silva.- Molecular Crowding and Hydration Regulating of G-Quadruplex Formation, by Daisuke Miyoshi, Takeshi Fujimoto and Naoki Sugimoto...
Supramolecular Polymers
Supramolecular Polymers, Second Edition details assembly processes and structure-function correlation in natural and synthetic self-assembling materials, focusing on developments occurred over the past five years. The book highlights developments in the synthesis of complex structures, chemical design principles, and theoretical models of
Vehicle and Automotive Engineering 2
This book presents the proceedings of the second Vehicle Engineering and Vehicle Industry conference, reflecting the outcomes of theoretical and practical studies and outlining future development trends in a broad field of automotive research. The conference’s main themes included design, manufacturing, economic and educational topics.
Microstructural and Mechanical Characterization of Alloys
This book contains manuscripts related to alloys (engineering materials) to discuss potential materials, methods for improvement of the strength and cyclic properties of alloys, the stability of microstructures, the possible application of new (or improved) alloys, and the use of treatment for alloy improvement. The broad spectrum of topics included in the articles of this Special Issue demonstrates that research into the microstructural and mechanical characteristics of alloys represents a contemporary field. These topics are also envisaged to be of interest to scientists in other research centers, and we can still expect new developments in this investigation field.
Recent Advances in Mechanical Engineering
This book presents the select proceedings of 2nd International Congress on Advances in Mechanical and Systems Engineering (CAMSE 2021). It focuses on the recent advances in mechanical and systems engineering and their growing demands for increase in several design and development activities. The contents in this book cover a blend of mechanical engineering, computer-aided engineering, control engineering, and systems engineering to design and manufacture useful products. Various additional topics covered include mechanics, machines, materials science, thermo-fluids, and control with state-of-the-art computational methods to analyse, innovate, design, implement and operate complex systems which are economic, reliable, efficient and sustainable. Given the contents, this book will be useful for researchers and professionals working in the field of mechanical engineering and allied fields.
53rd National Meeting of the Italian Society of Biochemistry and Molecular Biology (SIB) and National Meeting of Chemistry of Biological Systems – Italian Chemical Society (SCI - Section CSB)
The 53rd National Congress of the Italian Society of Biochemistry and Molecular Biology (SIB), which will be held in Riccione from 23 to 26 September, is characterised by the elevated scientific level and interdisciplinary interest of the numerous sessions in which it is organised. The Scientific Programme comprises three joint Symposia of the SIB and the Chemistry of Biological Systems section of the Italian Chemistry Society (SCI) on Molecular Systems Biology, Chemistry of Nucleic Acids, Protein and Drug Structure, and Environmental Biotechnology. These Symposia address groundbreaking arguments, making the joint interest of the two societies particularly fascinating; the joint organisation...
