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Biology of Phosphoinositides
This is a review of the current opinions on lipid signalling research with an emphasis on the integration of the use of lipid signals in signal transduction and membrane trafficking. These two areas have traditionally been seen as separate, but in the light of recent research it has become apparent that any work in this area must include the two, as this book does. In the text, control of synthesis, translocation, and degradation of phosphoinositides is given extensive coverage; there is specific discussion of the PH and FYVE lipid binding domains that allow lipids to control the movement, location, and activation-state of membrane proteins; the regulation of phospholipase C, phospholipase D, the phosphoinositide-3-kinases, chloride channel conductance by inositol (3,4,5,6) tetraphosphate, and of cytoskeletal protein activity by inositol lipids are all covered in depth.
Statistical Principles for the Design of Experiments
This book is about the statistical principles behind the design of effective experiments and focuses on the practical needs of applied statisticians and experimenters engaged in design, implementation and analysis. Emphasising the logical principles of statistical design, rather than mathematical calculation, the authors demonstrate how all available information can be used to extract the clearest answers to many questions. The principles are illustrated with a wide range of examples drawn from real experiments in medicine, industry, agriculture and many experimental disciplines. Numerous exercises are given to help the reader practise techniques and to appreciate the difference that good design can make to an experimental research project. Based on Roger Mead's excellent Design of Experiments, this new edition is thoroughly revised and updated to include modern methods relevant to applications in industry, engineering and modern biology. It also contains seven new chapters on contemporary topics, including restricted randomisation and fractional replication.
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The Film Club
Gilmour offers his 15-year-old son an unconventional deal: Jesse can drop out of school, but he must watch three movies a week of his father's choosing. Through their film club, father and son discuss everything from love to drugs--and their own lives change in surprising ways.
The Pursuit of Italy
Gilmour delves deep into Italy's cultural past to discover not only the effects of Risorgimento, but what, if anything, earlier generations have said about the concept of Italy. He examines what the Enlightenment thinkers believed, what Dante thought, what Machiavelli wanted and what the emperors made of it.
Drug Discovery for Psychiatric Disorders
This is a wide scope and in-depth coverage of the state of the art and future directions in drug discovery for major psychiatric disorders.
