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This volume features contributions from participants of an ESRF Workshop on "Systems Biology" held in Berkeley, USA, in November 2005. Significant progress has been made in developing technologies that enable systems interrogations at a molecular level. Recent successes and challenges of applying systems level measurements to the different steps of drug discovery and development in the pharmaceutical industry are summarized.
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The authoritative reference on High Content Screening (HCS) in biological and pharmaceutical research, this guide covers: the basics of HCS: examples of HCS used in biological applications and early drug discovery, emphasizing oncology and neuroscience; the use of HCS across the drug development pipeline; and data management, data analysis, and systems biology, with guidelines for using large datasets. With an accompanying CD-ROM, this is the premier reference on HCS for researchers, lab managers, and graduate students.
The Lloyd's Register of Shipping records the details of merchant vessels over 100 gross tonnes, which are self propelled and sea-going, regardless of classification. Before the time, only those vessels classed by Lloyd's Register were listed. Vessels are listed alphabetically by their current name.
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Winner of a Catholic Media Association Book Award The forgotten history of American terrorists who, in the name of God, conspired to overthrow the government and formed an alliance with Hitler. On January 13, 1940, FBI agents burst into the homes and offices of seventeen members of the Christian Front, seizing guns, ammunition, and homemade bombs. J. Edgar Hoover’s charges were incendiary: the group, he alleged, was planning to incite a revolution and install a “temporary dictatorship” in order to stamp out Jewish and Communist influence in the United States. Interviewed in his jail cell, the front’s ringleader was unbowed: “All I can say is—long live Christ the King! Down with C...