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Expanding from the classic use of immunosuppressants in transplantation and rejection, this current overview highlights their new roles in clinical medicine. Immunosuppressants are at the forefront of new treatment modalities. Individual chapters focus on their use not only in prevention or treatment of transplant rejection, but also on their use in immune-complex and autoimmune diseases, including rheumatoid arthritis; on combination therapies to achieve synergy in immunosuppression; on new drugs, low molecular weight chemicals, the use of antibodies and gene therapy; on immunological tolerance to prevent or inhibit transplant rejection; and how data derived from transplant studies can be applied to other avenues of immunosuppression. Clinicians and researchers will appreciate the scope of the work and the presentation of new approaches in the rapidly developing field of immunosuppression.
This book constitutes the thoroughly refereed post-proceedings of the International Computer Music Modeling and Retrieval Symposium, CMMR 2004, held in Esbjerg, Denmark in May 2004. The 26 revised full papers presented were carefully selected during two rounds of reviewing and improvement. Due to the interdisciplinary nature of the area, the papers address a broad variety of topics. The papers are organized in topical sections on pitch and melody detection; rhythm, tempo, and beat; music generation and knowledge; music performance, rendering, and interfaces; music scores and synchronization; synthesis, timbre, and musical playing; music representation and retrieval; and music analysis.
This book offers basic knowledge on Design Thinking as a method, process and philosophy. It presents thoughtful Design Thinking case examples and tools for nurses and other healthcare professionals, researchers, students and educators to support their development as creative and transformative leaders in their fields. Healthcare managers of the past viewed patients’ needs merely as targets for population-level health outcomes to be validated in the final phases of developing interventions and services. Today we know better. Patients’ needs and experiences should be viewed as sources of innovation at the front-end of the development process. It provides the basis for applying design think...
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Heart transplantation remains one of the major scientific achievements of twentieth century medicine. During the past four decades, it has evolved from an unproven experimental surgical technique to the most effective form of therapy for refractory end-stage heart disease. It has captured the public's imagination and expanded our understanding of fundamental immunologic mechanisms that are responsible for cellular and humorally-mediated immunity. Despite its successes, many clinical and scientific problems remain. One or more bouts of acute cellular or humoral (vascular) rejection will occur in over 75% of transplant recipients despite current immunosuppressive strategies. Further, rejection...
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