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Metal Ions in Neurological Systems
Metal ions in the brain are a necessity as well as a poison. The presence of metal ions in the active sites of biological catalysts or metalloproteins and in the biological functioning of nucleic acids is very well documented and they are required for brain activity. On the other hand, metals are very effective in generating oxidative stress. This effect does not only play a role in immunology but also is the root of practically all neurodegenerative disorders by inducing disease via the death of neurons. Managing metal ions in the brain could therefore be an important strategy in the search for therapeutic agents used in the treatment of neurodegenerative diseases. This new title gives an overview to key topics in the area of metal ions in the brain. It focuses on the role of metal ions in neurological systems by describing their advantageous functions as well as their poisonous features. It is therefore of interest for scientists in biochemistry and biophysics, physiology, toxicology as well as for physicians focused on this topic.
Synthetic Organic Sonochemistry
TEAN-LOUIS LUCHE A French poet of this eentury, Pierre Mae Orlan, wrote "Adventure does not exist, it is only in the mind of he who is pursuing it, and, as soon as it is at one's finger tips, it vanishes to come back to life, far away, in a different shape, at the frontiers of imagination". This sentence could be used to define the adventure that many sonochemists experienced. Most of them did not even suspect that the "laboratory trick" they were using was the first contact with a considerable amount of science. If a personal note is allowed here, it ean be interesting to mention the part played by chance in my involvement in sonochemistry. Almost 20 years ago, we had to perform an apparent...
Nishida Kitaro's Chiasmatic Chorology
Nishida Kitaro (1870–1945) is considered Japan's first and greatest modern philosopher. As founder of the Kyoto School, he began a rigorous philosophical engagement and dialogue with Western philosophical traditions, especially the work of G. W. F. Hegel. John W. M. Krummel explores the Buddhist roots of Nishida's thought and places him in connection with Hegel and other philosophers of the Continental tradition. Krummel develops notions of self-awareness, will, being, place, the environment, religion, and politics in Nishida's thought and shows how his ethics of humility may best serve us in our complex world.
Web Intelligence Meets Brain Informatics
This book constitutes the thoroughly refereed post-workshop proceedings of the First WICI International Workshop on Web Intelligence meets Brain Informatics, WImBI 2006, which was held in Beijing, China, in December 2006. The workshop explores a new perspective of Web Intelligence (WI) research from the viewpoint of Brain Informatics (BI). The 26 revised full-length papers presented together with three introductory lectures have been carefully reviewed and selected.
Novel Gene Therapy Approaches
Gene therapy has the potential to be a tailor-made therapeutic with increased specificity and decreased side effects that can offer a "cure" for many disorders. The aim of this book is to provide up-to-date reviews of the rapidly growing field of gene therapy. Chapters cover a large range of topics including methods of gene delivery, and identification of targets with several papers on cancer gene therapy. If more people become aware of the true nature and potential of gene therapy, perhaps we can achieve the full benefit of such an innovative approach for the treatment of a range of diseases, including cancer.
Classic and Advanced Ceramics
Based on the author's lectures to graduate students of geosciences, physics, chemistry and materials science, this didactic handbook covers basic aspects of ceramics such as composition and structure as well as such advanced topics as achieving specific functionalities by choosing the right materials. The focus lies on the thermal transformation processes of natural raw materials to arrive at traditional structural ceramics and on the general physical principles of advanced functional ceramics. The book thus provides practice-oriented information to readers in research, development and engineering on how to understand, make and improve ceramics and derived products, while also serving as a rapid reference for the practitioner. The choice of topics and style of presentation make it equally useful for chemists, materials scientists, engineers and mineralogists.
Index Medicus
Vols. for 1963- include as pt. 2 of the Jan. issue: Medical subject headings.
Molecular Pathology of the Prions
Internationally recognized investigators review the latest developments in, and novel approaches to, understanding the prion protein and prion diseases at the molecular level. Utilizing a variety of cutting-edge techniques, these distinguished scientists seek to define the normal function of a prion protein, to detect and measure the early immune response to prion disease, and to discover possible therapeutic targets. They also use transgenic mice and new electrophysiological investigations to elucidate the pathogenetic mechanisms involved in prion diseases. State-of-the-art and richly insightful, Molecular Pathology of the Prions captures for basic and clinical neuropathologists the latest developments and approaches to understanding the pathogenesis of prion diseases, and by analogy suggests possible research techniques for the more common proteinopthies, such as Alzheimer's and Parkinson's diseases.
An Inquiry into the Good
"An Inquiry into the Good, the earliest work of Kitarō Nishida, established its author as the foremost Japanese philosopher of the twentieth century. The book represents the foundation of Nishida's philosophy, which reflects both his deep study of Zen Buddhism and his thorough analysis of Western philosophy. In this important new translation, two scholars -- one Japanes and one American -- have worked together to present a lucid and accurate rendition of this basic work. They have also included an enlightening introduction and ample notes to aid the Western reader. Nishida sets forth the notion of "pure experience"--The concept that pure, or direct, experience precedes the separation of sub...
