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Sequence-specific DNA Binding Agents
The binding of antibiotics and drugs to DNA is a fast developing area of research with important applications in medicine, particularly the treatment of cancer. Sequence-specific DNA Binding Agents uniquely discusses key aspects of this topic, providing a novel perspective on the subject. Written by experts in the field, this book discusses diverse modes of binding of antibiotics and drugs to DNA, emphasising matters that are important or promising for cancer treatment. Chapters discuss established agents like actinomycin D but also look at novel drugs with strong potential in chemotherapy such as new topoisomerase inhibitors, telomerase inhibitors, peptide nucleic acids and triple helix-forming oligonucleotides. There are also sections discussing methodological advances including computational methods, slow kinetics, melting curve analysis and approaches to medicinal chemistry. Finally there is a section on RNA structure and its potential as a drug target. The book is ideal for researchers in industry and academia who require a comprehensive source of reference to this rapidly expanding subject.
Integrated Crop Protection
This book discusses the constraints on biological control ranging from the difficulty of convincing growers that they should infest their crops artificially to the effect of cultural techniques.
Frontiers in Medicinal Chemistry
""Frontiers in Medicinal Chemistry" is an Ebook series devoted to the review of areas of important topical interest to medicinal chemists and others in allied disciplines. "Frontiers in Medicinal Chemistry" covers all the areas of medicinal chemistry, incl"
Progress in Nucleic Acid Research and Molecular Biology
Nucleic acids are the fundamental building blocks of DNA and RNA and are found in virtually every living cell. Molecular biology is a branch of science that studies the physicochemical properties of molecules in a cell, including nucleic acids, proteins, and enzymes. Increased understanding of nucleic acids and their role in molecular biology will further many of the biological sciences including genetics, biochemistry, and cell biology. Progress in Nucleic Acid Research and Molecular Biology is intended to bring to light the most recent advances in these overlapping disciplines with a timely compilation of reviews comprising each volume.
Genetic Engineering
None
DNA Binders and Related Subjects
with contributions by numerous experts
Biaxial/Multiaxial Fatigue and Fracture
The European Structural Integrity Society (ESIS) Technical Commitee on Fatigue of Engineering Materials and Structures (TC3) decided to compile a Special Technical Publication (ESIS STP) based on the 115 papers presented at the 6th International Conference on Biaxial/Multiaxial Fatigue and Fracture. The 25 papers included in the STP have been extended and revised by the authors. The conference was held in Lisbon, Portugal, on 25-28 June 2001, and was chaired by Manual De Freitas, Instituto Superior Tecnico, Lisbon. The meeting, organised by the Instituto Superior Tecnico and sponsored by the Portuguese Minesterio da Cienca e da Tecnologia and by the European Structural Integrity Society, was...
Cancer Therapeutics
Cancer drug discovery has been and continues to be a process of ingenuity, serendip ity, and dogged determination. In an effort to develop and discover better therapies against cancer, investigators all over the world have increased our knowledge of cell biology, biochemistry, and molecular biology. The goal has been to define therapeuti cally exploitable differences between normal and malignant cells. The result has been an increased understanding of cellular and whole-organism biology and an increased respect for the flexibility and resiliency ofbiologically systems. Thus, as some new therapeutic targets have been defined and new therapeutic strategies have been attempted, so have some new...
