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The book aims at giving the methodological framework for design decision support systems. Several applications are also described in detail, ranging from environment control, production planning, transportation planning. The book is of special interest to operations researchers, environment specialists, production planners, and transportation engineers.
In The Responsible Fashion Company, Rinaldi and Testa argue that the fashion industry is at a crossroads: the need for a global shift to a sustainable model has never been more urgent. Yet, they demonstrate that we are witnessing a revolution led by conscious consumers and enlightened companies, who are redefining the rules of the fashion market. The question is: when will the rest of the industry catch up? Rinaldi and Testa raise a fundamental but often neglected issue in the fashion sustainability debate: long-term equilibrium can only be achieved by integrating economic goals with environmental, social and ethical values. "The Responsible Fashion Company" provides a clear overview of the ...
The construction of mathematical models is an essential scientific activity. Mathematics is associated with developments in science and engineering, but more recently mathematical modelling has been used to investigate complex systems that arise in other fields. This book demonstrates the application of mathematics to research topics in ecology and environmental science, health and medicine, phylogenetics and neural networks, theoretical chemistry, economics and management.
Hydraulic, hydrologic and water resources engineers have been concerned for a long time about failure phenomena. One of the major concerns is the definition of a failure event E, of its probability of occurrence PtE), and of the complementary notion of reliability. However, as the stochastic aspects of hydraulics and water resources engineering were developed, words such as "failure," "reliability," and "risk" took on different meanings for different specialists. For example, "risk" is defined in a Bayesian framework as the expected loss resulting from a precisely defined failure event, while according to the practice of stochastic hydraulics it is the probability of occurrence of a failure ...
Mathematics and Computer Science III contains invited and contributed papers on combinatorics, random graphs and networks, algorithms analysis and trees, branching processes, constituting the Proceedings of the Third International Colloquium on Mathematics and Computer Science, held in Vienna in September 2004. It addresses a large public in applied mathematics, discrete mathematics and computer science, including researchers, teachers, graduate students and engineers.
The perceived lack of drug discovery productivity in recent times has led to much debate in the pharmaceutical/biotechnology industry as escalating R&D costs are not being matched by increased output. Few observers doubt that selecting the right targets, ie those which are critical to disease pathology and are 'druggable', is the best starting point for improved productivity.The seven chapters of this volume describe recent progress towards drugs acting at a range of 'druggable' targets. One chapter addresses kinases, one covers an ion channel, two proteases are featured and three of the chapters cover G-protein coupled receptors, which has historically perhaps been the most fruitful area for medicinal chemists.*Presents the latest research in the field of drug discovery *Publishes on an annual basis to bring you the most innovative updates in medicinal chemistry *Available as an online resource via ScienceDirect
This volume covers the new methodological advances in NMR spectroscopy that have been developed since the publication of the first edition. These include: 'indirect detection' methods, particularly proton-detected carbon-13 spectra, which have profoundly increased NMR sensitivities; 3- and even higher- dimensional NMR methods which have further increased spectral resolving and correlating power; powerful new computer programs which assist in all phases of data analysis and ultimately make possible rigorous interpretations of complex 2D and higher- dimensional NMR spectra using molecular mechanics and dynamics calculations; and field gradient technology which makes it possible to acquire 2D and higher-dimensional spectra of concentrated samples very rapidly, greatly reducing experiment times. This new edition retains the original format of the first edition with introductory chapters covering descriptions, basic theoretical treatments and experimental aspects of the methods. These are followed by applications chapters representing a broad sampling of important research areas and compound classes
This book provides a practically applicable guide to the use of multimodality imaging for managing aortic valve disorders. Details of how to successfully diagnose a range of aortic valve diseases is presented, with detailed information covered on the techniques and relevant criteria for pre-operative screening, surgical and transcatheter planning, intraprocedural imaging and related postoperative follow-up. Multimodality Imaging for Cardiac Valvular Interventions, Volume 1 Aortic Valve: From Diagnosis to Decision-Making enables the reader to develop a thorough understanding and confidence of how to make appropriate clinical decisions when confronted by a range of aortic valve diseases. It is therefore a key resource for practicing cardiac imagers, cardiologists and interventional cardiologists who encounter these patients in their day-to-day clinical practice and trainees in cardiology seeking insight on the appropriate management of these patients.