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Therapeutic Oligonucleotides
This book provides a compelling overall update on current status of RNA interference
Microquasars
The Third Microquasar Workshop (or the 'Fifth' Workshop on Galactic Relativ istic Jet Sources), was held in Granada, Andalucia (Spain) on 11-13 September 2000. The aim of this workshop in Granada, following the previous Microquasar Workshops in Greenbelt (1997) and Paris (1998) and the Workshops on galactic sources with relativistic jets in Jodrell Bank (1996) and Milton Keynes (1998), was to focus on the theoretical and observational aspects of microquasars. The study of microquasars, the sources in our Galaxy displaying powerful re lativistic jets, is a rapidly advancing field in astrophysics. The new instrumentation on ground (MERLIN, SCUBA, VLA, VLT) and aboard satellites (ASCA, BSAX, IS...
Biotherapeutics
Biotherapeutics are often considered to be beyond the reach of the medicinal chemist, but this book demonstrates that chemistry has an essential role in the future success of this area.
Oligonucleotides as Therapeutic Agents
The use of oligonucleotides as therapeutic agents rests upon their ability to interfere, in a sequence-specific manner, with the fundamental machinery of protein synthesis either by binding to the mRNAs transcribed from a gene or by binding directly to a target gene. This approach can be used not only for inhibition of the synthesis of host proteins but also of those required by invading pathogens. Potential therapeutic applications are enormous, ranging over hypertension, cardiovascular disease, autoimmune disease, vital and other parasitic infections (especially HIV), and cancer. This book discusses the chemistry and pharmacokinetics of oligonucleotides and their analogues, and surveys the results of structure-activity studies and current clinical trials. It also critically reviews the problems with antisense therapy, such as the enzymatic destruction of oligonucleotides, the doses required for a therapeutic response, the difficulty in directing oligonucleotides to particular target tissues and cells, the need for parenteral administration, and doubts concerning the mechanism of action (especially problems associated with non-specific binding to proteins) and long-term effects.
Database Systems for Advanced Applications
This two volume set LNCS 6587 and LNCS 6588 constitutes the refereed proceedings of the 16th International Conference on Database Systems for Advanced Applications, DASFAA 2011, held in Saarbrücken, Germany, in April 2010. The 53 revised full papers and 12 revised short papers presented together with 2 invited keynote papers, 22 demonstration papers, 4 industrial papers, 8 demo papers, and the abstract of 1 panel discussion, were carefully reviewed and selected from a total of 225 submissions. The topics covered are social network, social network and privacy, data mining, probability and uncertainty, stream processing, graph, XML, XML and graph, similarity, searching and digital preservation, spatial queries, query processing, as well as indexing and high performance.
Anti-AIDS Drug Development
Curative anti-AIDS drug therapy still remains as an unconquered hurdle to drug research. This book covers significant aspects that are involved in the search, design and development of potential anti-AIDS agents with emphasis on areas related to drug development. These include enzyme inhibitors (reverse transcriptase, protease, glucosidase), inhibitors of gene expression (oligonucleotides), viral-binding inhibitors (anionic compounds and CD4 mimetics) and various plant derived products. A focus of this book is the medicinal chemistry of these classes of compounds. In addition, other areas that are pertinent to drug development are also addressed. These include HIV regulatory proteins, the development of anti-HIV-1 assays and resistance to anti-HIV-1 agents.
eBook: Database Systems Concepts 6e
eBook: Database Systems Concepts 6e
Climate Change, Air Pollution and Global Challenges
There are significant pressures from climate change and air pollution that forests currently face. This book aims to increase understanding of the state and potential of forest ecosystems to mitigate and adapt to climate change in a polluted environment. It reconciles process-oriented research, long-term monitoring and applied modeling through comprehensive forest ecosystem research. Furthermore, it introduces "forest super sites for research for integrating soil, plant and atmospheric sciences and monitoring. It also provides mechanistic and policy-oriented modeling with scientifically sound risk indications regarding atmospheric changes and ecosystem services. - Identifies current knowledge gaps and emerging research needs - Highlights novel methodologies and integrated research concepts - Assesses ecological meaning of investigations and prioritizing research need
