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Lu's Basic Toxicology
This new edition of our bestselling book, Lu's Basic Toxicology, provides a number of key benefits that make it a must-read for toxicology specialists worldwide, including:Revision of a Bestseller - the new Sixth Edition provides the critical updates toxicologists need to keep up with the changing timesNew Information - on over-the-counter preparat
Lu's Basic Toxicology
This classic textbook now enters its forth edition, offering a distillation of decades of research and teaching experience in toxicology. Known all over the world after its translation into six languages, Lu's Basic Toxicology: Fundamentals, Target Organs, and Risk Assessment is a benchmark text that brings clarity and insight into a rapidly evolving subject. Noted for its concise yet broad coverage of the subject, this new edition includes new chapters on over-the counter preparations, lactation and occupational toxicology. In addition, it covers: " The action of chemicals that cause cancer, mutations, congenital malformations and organ or system specific effects " Why chemical target speci...
Review of the U.S. Navy Environmental Health Center's Health-Hazard Assessment Process
A large number of chemicals are used on land at shore facilities, in the air in combat and reconnaissance aircraft, on seas around the world in surface vessels, and in submarine vessels by the navy and marine corps. Although the chemicals used are for the large part harmless, there is a significant amount of chemicals in use that can be health hazards during specific exposure circumstances. The Navy Environmental Health Center (NEHC) is primarily tasked with assessing these hazards. The NEHC completes its tasks by reviewing toxicological and related data and preparing health-hazard assessments (HHAs) for the different chemicals. Since the NEHC is continually asked to develop these HHAs, the ...
Acute Exposure Guideline Levels for Selected Airborne Chemicals
At the request of the Department of Defense and the Environmental Protection Agency, the National Research Council has reviewed the relevant scientific literature compiled by an expert panel and established Acute Exposure Guideline Levels (AEGLs) for several chemicals. AEGLs represent exposure levels below which adverse health effects are not likely to occur and are useful in responding to emergencies, such as accidental or intentional chemical releases in community, workplace, transportation, and military settings, and for the remediation of contaminated sites. Three AEGLs are approved for each chemical, representing exposure levels that result in: 1) notable but reversible discomfort; 2) long-lasting health effects; and 3) life-threatening health impacts. This volume in the series includes AEGLs for bis-chloromethyl ether, chloromethyl methyl ether, chlorosilanes, nitrogen oxides, and vinyl chloride.
Toxicology of Metals, Volume I
This volume offers the most comprehensive presentation available on metal toxicology. It discusses not only metals but also the toxic endpoints, such as neurotoxicity, renal toxicity, and cancer induction. Chapters are written by experts in their respective fields, focusing on carcinogenesis and human exposures and highlighting the major aspects and issues of toxicity in general.
Thirteenth Interim Report of the Subcommittee on Acute Exposure Guideline Levels
Formed in 1995 by EPA, several other federal and state agencies, and several private organizations, the National Advisory Committee on Acute Exposure Guideline Levels for Hazardous Substances (referred to as the NAC) develops, reviews, and approves acute exposure guideline levels (AEGLs) for up to 400 extremely hazardous substances (EHSs). AEGLs have a broad array of potential applications for federal, state, and local governments and for the private sector. They are necessary for prevention and emergency-response planning for potential releases of EHSs, either from accidents or as a result of terrorist activities. This report includes an assessment of the NAC's draft AEGLs documents for the following 10 chemicals: 1, 4-dioxane; chloroform; carbon tetrachloride; sulfur dioxide; cis, trans 1,-2 dichloroethylene; monochloroacetic acid; carbon monoxide; fluorine; methanol; and phenol.
Toxicological Profile for Vinyl Chloride (VC) (update)
Characterizes the toxicologic and adverse health effects info. for VC, which has been found in toxic sites. VC is used to make polyvinyl chloride (PVC), which is used to make pipes, packaging materials, furn. and auto upholstery, wall coverings, housewares, and auto parts. This profile includes: (a) The examination and interpretation of toxicologic info. on VC to ascertain the acute, subacute, and chronic health effects (ASCHA); (b) A determin¿n. of whether adequate info. on the health effects of VC is available to determine whether there is significant risk to human health of ASCHA; and (c) Ident. of toxicologic testing needed to identify the types or levels of exposure that may present significant risk of adverse health effects in humans. Illus. A print on demand report.
Studies in Natural Products Chemistry
Natural products in the plant and animal kingdom offer a huge diversity of chemical structures that are the result of biosynthetic processes that have been modulated over the millennia through genetic effects. With the rapid developments in spectroscopic techniques and accompanying advances in high-throughput screening techniques, it has become possible to isolate and then determine the structures and biological activity of natural products rapidly, thus opening up exciting opportunities in the field of new drug development to the pharmaceutical industry. Studies in Natural Products Chemistry covers the synthesis or testing and recording of the medicinal properties of natural products, providing cutting edge accounts of the fascinating developments in the isolation, structure elucidation, synthesis, biosynthesis and pharmacology of a diverse array of bioactive natural products. - Focuses on the chemistry of bioactive natural products - Contains contributions by leading authorities in te field - Presents sources of new pharmacophores
Toxicologic Assessment of Jet-Propulsion Fuel 8
This report provides a critical review of toxicologic, epidemiologic, and other relevant data on jet-propulsion fuel 8, a type of fuel in wide use by the U.S. Department of Defense (DOD), and an evaluation of the scientific basis of DOD's interim permissible exposure level of 350 mg/m3
Standing Operating Procedures for Developing Acute Exposure Guideline Levels for Hazardous Chemicals
Standing Operating Procedures for Developing Acute Exposure Guideline Levels for Hazardous Chemicals contains a detailed and comprehensive methodology for developing acute exposure guideline levels (AEGLs) for toxic substances from inhalation exposures. The book provides guidance on what documents and databases to use, toxicity endpoints that need to be evaluated, dosimetry corrections from animal to human exposures, selection of appropriate uncertainty factors to address the variability between animals and humans and within the human population, selection of modifying factors to address data deficiencies, time scaling, and quantitative cancer risk assessment. It also contains an example of a summary of a technical support document and an example of AEGL derivation. This book will be useful to persons in the derivation of levels from other exposure routesâ€"both oral and dermalâ€"as well as risk assessors in the government, academe, and private industry.
