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Pediatric Neuroendocrinology
The neuroendocrine system plays a pivotal role in the control of growth, puberty, reproduction, and intermediate metabolism. This title presents the research on neuroendocrine physiology, advances in the control of the onset of puberty and its disorders, and basic and clinical aspects of the GH/IGF-1 and hypothalamic-pituitary-adrenal axes.
Advanced Therapies in Pediatric Endocrinology and Diabetology
Dealing with current hot topics, this book aims to provide an update on advances in the treatment of endocrine disorders. The chapters cover innovative therapeutic approaches to type 1 diabetes, such as artificial pancreas and islet transplantation. Additionally, novel pharmacological interventions for patients with obesity and the metabolic syndrome, as well as with adrenal and gonadal disorders are provided. Furthermore, recent developments in growth-promoting therapies, such as the C-type natriuretic peptide analog to treat achondroplasia, as well as antioxidant and gene replacement therapies in patients with adrenoleukodystrophy, are described. Worldwide renowned experts share their experience and cutting edge research in Advanced Therapies in Pediatric Endocrinology and Diabetology, which makes it a useful and interesting resource for every pediatric endocrinologist, not only those active in clinical research, but also those involved in the management of children with endocrine diseases in daily practice.
Congenital Endocrinopathies
In recent years, substantial progress in gene technology has greatly improved the understanding of the pathogenesis of paediatric endocrine diseases as well as opened new diagnostic and therapeutic possibilities. This volume, based on a symposium held in Genoa in January 2007, reviews normal and abnormal hypothalamic-pituitary development affecting growth hormone (GH) secretion and defects of the GH-IGF-I axis influencing GH and IGF-I action. Abnormalities of the pituitary-gonadal axis affecting normal puberty are discussed together with defects of steroidogenesis involving both adrenal and gonadal development. The effect of glucocorticoid hormone programming in early life and defects of G p...
Growth Hormone Secretagogues
The traditional concept of a neuroendocrine mechanism for regulation of growth hormone (GH) secretion is based in large part on the work of Roger Guillemin. The work of Dr. Guillemin, who was awarded the 1977 Nobel Prize in Physiology and Medicine, supported the view that quantita tive change in GH secretion was the net result of pituitary stimulation and inhibition by the hypothalamic neurohormones, GH releasing hormone (GHRH), and somatostatin (somatotropin release inhibiting factor; SRIF), respectively. During the 1970s, another endocrine research pioneer, Dr. Cyril Bowers, discovered that structural modification of enkephalin re sulted in a family of peptides with GH releasing properties...
Yearbook of Pediatric Endocrinology 2007
The body of knowledge in most medical specialties is rapidly expanding, making it virtually impossible to follow all advances in clinical and basic sciences that are relevant to a given field. This is particularly true in pediatric endocrinology, at the cross-road of pediatrics, endocrinology, development and genetics. The 'Yearbook of Pediatric Endocrinology 2007' brings you abstracts of articles that reported the year's breakthrough developments in the basic sciences and evidence-based new knowledge in clinical research and clinical practice that are relevant to the field. Twelve Associate Editors and their co-authors selected from several thousand papers those that brought the most meanin...
Basic and Clinical Aspects of Growth Hormone
In this era of proliferation of synthetic growth hormone in the marketplace, there is a parallel and accentuated interest in growth hormone in the scientific arena. Because many more people can be treated with available growth hormone, clinicians must be prepared to answer hard questions regarding appropriate therapeutic usage and their decisions should be based on substantiated research in growth hormone. In June 1987, an international group of basic and clinical inves tigators gathered in Tampa, Florida, to address these issues and to further explore the very nature of growth hormone. The presentations contained within this book bring together their most current and vital research related ...
Growth Hormone Secretagogues in Clinical Practice
Recognizing the urgent need for an up-to-date review of new and innovative research on growth hormone (GH) secretagogues, this exclusive work furnishes the state of the art on the mechanisms of action, design, synthesis, evaluation, and clinical applications of GH secretagogues, including orally active and xenobiotic GH-releasing compounds. Beginning with a thorough historical perspective on the discovery and evolution of GH-releasing peptides (GHRPs) as therapeutic agents, Growth Hormone Secretagogues in Clinical Practice analyzes structural requirements for GH secretagogue efficacy demonstrates the use of mathematical models to predict differential values of individual stimuli for GH secre...
Coequal aand Counterbalanced
God created woman and man so that they would be consubstantial and coequal and that they would manifest perfectly counterbalanced complementarity. The relationship of the two halves of humanity was to be one of love, mutuality, and fulfillment. By recovering the Hebraic understanding of God's blueprint for them, both women and men can finally experience the relationship that God designed to be heaven on earth; The God-Designed Two-in-One, Coequal, Counterbalanced Partnership; Designer-Fashioned Woman; Gender Self-Identity and Self-Fulfillment; Spare Ribs and Afterthoughts?' Marriage as Heaven on Earth. \Whatever your race, ethnicity, gender, faith, or social status, this book and the other volumes in this series will literally set you free from misconceptions that have long perverted relationships between women and men. As you reconnect with the Hebraic foundations of your faith, you will rediscover God's original design for humanity, and you will come to understand, respect, and honor the different God-designed distinctives, preferences, and roles for women and men that counterbalance and complement each other in mutuality and love.
