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The Fungal Cell Wall
This book illustrates, that the fungal cell wall is critical for the biology and ecology of all fungi and especially for human fungal pathogens. Readers will learn, that the composition of the fungal cell wall is a unique structure, which cannot be found in the human host. Consequently, the chapters outline, how the immune systems of both animals and humans have evolved to recognize conserved and unique elements of the fungal cell wall. As an application example, the authors also show, that the three-dimensional structures of the cell wall are excellent targets for the development of antifungal agents and chemotherapeutic strategies. With the combination of biological findings and medical outlooks, this volume is a fascinating read for scientists, clinicians and biomedical students.
Orthogeriatrics
This new open access edition supported by the Fragility Fracture Network aims at giving the widest possible dissemination on fragility fracture (especially hip fracture) management and notably in countries where this expertise is sorely needed. It has been extensively revised and updated by the experts of this network to provide a unique and reliable content in one single volume. Throughout the book, attention is given to the difficult question of how to provide best practice in countries where the discipline of geriatric medicine is not well established and resources for secondary prevention are scarce. The revised and updated chapters on the epidemiology of hip fractures, osteoporosis, sar...
Portrait of the Artist as a Child
Res. en portugués
Immunity to Human Fungal Pathogens: Mechanisms of Host Recognition, Protection, Pathology, and Fungal Interference
Fungi are found in virtually every environment, and comprise a significant portion of the normal microflora of healthy individuals. Some species of fungi are aeroallergen sources capable of inducing sensitization and causing exacerbation of asthma and respiratory allergy. Others are transmissible between hosts and may cause no symptoms in healthy individuals. However, immune suppressed individuals may develop invasive disease marked by tissue invasion with a potential for widespread dissemination. Existing therapies for patients consist of antifungal drugs, yet these require prolonged administration with the possibility of adverse side effects, and may be rendered ineffective by the emergenc...
The Paleogene and Neogene of Western Iberia (Portugal)
This volume includes a general description of the Portuguese Cenozoic basins in the Iberian tectonic context. The main stratigraphic units, including sedimentological, stratigraphical and palaeontological data, are characterized. Correlations between different sectors are presented as well as general paleogeographical evolution maps. The volume includes a general bibliography concerning the Cenozoic of Portugal.
Product Lifecycle Management in the Digital Twin Era
This book constitutes the refereed post-conference proceedings of the 16th IFIP WG 5.1 International Conference on Product Lifecycle Management, PLM 2019, held in Moscow, Russia, in July 2019. The 38 revised full papers presented were carefully reviewed and selected from 63 submissions. The papers are organized in the following topical sections: 3D modelling and data structures; PLM maturity and industry 4.0; ontologies and semantics; PLM and conceptual design; knowledge and change management; IoT and PLM; integrating manufacturing realities; and integration of in-service and operation.
Wearable Sensor Technology for Monitoring Training Load and Health in the Athletic Population
Several internal and external factors have been identified to estimate and control the psycho-biological stress of training in order to optimize training responses and to avoid fatigue, overtraining and other undesirable health effects of an athlete. An increasing number of lightweight sensor-based wearable technologies (“wearables”) have entered the sports technology market. Non-invasive sensor-based wearable technologies could transmit physical, physiological and biological data to computing platform and may provide through human-machine interaction (smart watch, smartphone, tablet) bio-feedback of various parameters for training load management and health. However, in theory, several wearable technologies may assist to control training load but the assessment of accuracy, reliability, validity, usability and practical relevance of new upcoming technologies for the management of training load is paramount for optimal adaptation and health.
