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Immunity to Human Fungal Pathogens: Mechanisms of Host Recognition, Protection, Pathology, and Fungal Interference
Fungi are found in virtually every environment, and comprise a significant portion of the normal microflora of healthy individuals. Some species of fungi are aeroallergen sources capable of inducing sensitization and causing exacerbation of asthma and respiratory allergy. Others are transmissible between hosts and may cause no symptoms in healthy individuals. However, immune suppressed individuals may develop invasive disease marked by tissue invasion with a potential for widespread dissemination. Existing therapies for patients consist of antifungal drugs, yet these require prolonged administration with the possibility of adverse side effects, and may be rendered ineffective by the emergenc...
Advances in Aspergillus fumigatus pathobiology
Aspergillus fumigatus is a human fungal pathogen that causes invasive aspergillosis (IA), a major infectious cause of death in the expanding population of immunocompromised individuals such as cancer patients and transplant recipients. The mortality of IA remains high (30-70%) and emerging resistance to triazoles, the first-line antifungal drug class, is of particular concern. Second-line therapies for IA are limited by their toxicity (polyenes) or their lack of fungicidal activity (echinocandins). Identification of novel antifungal targets is an urgent need for improving the outcome of IA. A. fumigatus is a filamentous fungus exhibiting a complex developmental cycle and elaborate mechanisms...
Desconstruindo o Zika
Em 2015, uma pandemia viral explodiu no noticiário, apoiada por alarmes de saúde pública de que o flavivÃrus Zika — por décadas reconhecido como inofensivo — de repente era responsável pela microcefalia congênita (cabeças pequenas, intelecto diminuÃdo). Especialistas alinhados à OMS recomendaram que as mulheres abandonassem o parto. Previsivelmente, seguiu-se um pânico em massa. Nenhuma doença médica humana jamais foi atribuÃda diretamente ao Zika — um quase gêmeo da Dengue, que por si só causa anualmente milhões de casos de "febre quebra-ossos" na América do Sul; nunca com qualquer microcefalia associada! Profissionais de pesquisa médica no Brasil trataram as alegaÃ...
Advances in Solid Oxide Fuel Cells III, Volume 28, Issue 4
Papers from The American Ceramic Society's 31st International Conference on Advanced Ceramics and Composites, held in Daytona Beach, Florida, January 21-26, 2007. Content includes papers on recent technical progress by national laboratories, universities and private industries on solid oxide fuel cell technology including SOFC component materials, processing, cell/stack fabrication and design, electrochemical performance and stability, long-term chemical interactions, interface engineering, modeling, test procedures and performance analysis.
The Existence or Non-existence of Race?: Forensic Anthropology, Population Admixture, and the Future of Racial Classification in the U.S.
This collection contains music score for 17 marches composed by Ion S. Melnik. The selection contains sheet music for the piano only and instrumental music (piano, violin, and violoncello).
From Here to Yonder
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