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MOGAD, Current Knowledge and Future Trends
Myelin oligodendrocyte glycoprotein (MOG) antibody disease (MOGAD) is a neurological, immune-mediated disorder targeting MOG protein, located on the outermost myelin sheaths in the central nervous system. The diagnosis is confirmed when serum MOG antibody is found in patients in the context of inflammatory attacks of the central nervous system, usually with the brain, brainstem, optic nerve, and spinal cord. Although MOGAD manifestations can fulfill diagnostic criteria for Neuromyelitis optica disorder (NMOSD), evidence suggests that they have distinct immunological mechanisms. Similar to NMOSD, patients with persistent MOG antibodies are at risk for recurrent events. Recovery of MOGAD is generally reasonable. However, some patients get disability after a severe acute attack. Treatment for an acute attack is typically intravenous high-dose steroids, plasma exchange (PLEX), or intravenous immunoglobulin (IVIG). Maintenance therapy with immunosuppressants, i.e., azathioprine, mycophenolate, rituximab, etc., usually prevents future attacks, although they have long-term side effects. Therefore, it is still controversial how long treatment should be continued.
In Search of Common Ground on Abortion
This book brings together academics, legal practitioners and activists with a wide range of pro-choice, pro-life and other views to explore the possibilities for cultural, philosophical, moral and political common ground on the subjects of abortion and reproductive justice more generally. It aims to rethink polarized positions on sexuality, morality, religion and law, in relation to abortion, as a way of laying the groundwork for productive and collaborative dialogue. Edited by a leading figure on gender issues and emerging voices in the quest for reproductive justice - a broad concept that encompasses the interests of men, women and children alike - the contributions both search for 'common ground' between opposing positions in our struggles around abortion, and seek to bring balance to these contentious debates. The book will be valuable to anyone interested in law and society, gender and religious studies and philosophy and theory of law.
Case Reports in Multiple Sclerosis and Neuroimaging, volume III - 2023
This Research Topic aims to collect all the Case Reports submitted to the Multiple Sclerosis and Neuroimmunology. All the Case Reports submitted to this collection will be personally assessed by a senior Associate Editor before the beginning of the peer-review process. Please make sure your article adheres to the following guidelines before submitting it. Case Reports highlight unique cases of patients that present with an unexpected diagnosis, treatment outcome, or clinical course. Only Case Reports that are original and significantly advance the field will be considered: 1) RARE case with TYPICAL features. 2) FREQUENT case with ATYPICAL features. 3) Cases with a convincing response to new treatments, i.e. single case of off-label use.
Sex differences in immunometabolism, prophylaxis and therapy
Immune system function and metabolism are profoundly intertwined on a whole-body and cellular level. This is reflected in both homeostatic processes during growth and development and in pathological states. For instance, chronic inflammation in adipose tissue is a strong predictor of insulin resistance and metabolic syndrome, overall increasing risk for type 2 diabetes and associated co-morbidities in obese individuals. Simultaneously, increased visceral adiposity is linked with a delayed or deficient immune response to infection. On the cellular level, immune cell phenotype is intimately connected with metabolic status. In states of high energy demand immune cells rely on glycolysis for producing ATP, while oxidative phosphorylation is the preferred energy source in resting and regulatory states.
The Clinical Neuropsychiatry of Multiple Sclerosis
This book provides a detailed survey of the emotional, behavioural and cognitive disorders prevalent among patients with Multiple Sclerosis (MS), including depression, mania, psychosis, pathological laughing and crying, and cognitive dysfunction. Attention has tended to focus on the physical aspects of MS, the commonest source of neurological disability in young and middle-aged adults, but recognition and treatment of the behavioural changes associated with the disease can be equally important in improving quality of life for the patient. For each of the neuropsychiatric disorders associated with MS, clear clinical guidelines are given for diagnosis and treatment, there is a detailed review of the literature, and case vignettes are incorporated. There are chapters on screening and neuroimaging and a final chapter examines the broader concept of subcortical white matter dementia. This book will be of interest to psychiatrists, neurologists, psychologists, nurses and other professionals involved in the management of patients with MS.
Multiple Sclerosis
Presents a practical and accessible approach to the diagnosis and management of multiple sclerosis in hospital and outpatient settings.
Multiple Sclerosis Therapeutics
This textbook examines the most important aspects of multiple sclerosis that impact on clinical trial design, on the development of new disease therapies and on patient care. The international team of contributors discuss the clinical course of multiple sclerosis, its clinical heterogeneity, the presence of subclinical disease activity which occurs during the early stages of the disease. Multiple sclerosis presents clinical challenges: from unexpected and irregular relapses to profressive deterioration.
