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Genetic Determinants of Human Longevity
In the last two decades, due to the continuous increase of lifespans in Western societies, and the consequent growing of the elderly population, have witnessed an increase in the number of studies on biological and molecular factors able to promote healthy aging and reach longevity. The study of the genetic component of human longevity demonstrated that it accounts for 25% of intra population phenotype variance. The efforts made to characterize the genetic determinants suggested that the maintenance of cellular integrity, inflammation, oxidative stress response, DNA repair, as well as the use of nutrients, represent the most important pathways correlated with a longer lifespan. However, alth...
Role of Stem Cells in Skeletal Muscle Development, Regeneration, Repair, Aging and Disease
Adult stem cells are responsible for tissue regeneration and repair throughout life. Their quiescence or activation are tightly regulated by common signalling pathways that often recapitulate those happening during embryonic development, and thus it is important to understand their regulation not only in postnatal life, but also during foetal development. In this regard, skeletal muscle is an interesting tissue since it accounts for a large percentage of body mass (about 40%), it is highly amenable to intervention through exercise and it is also key in metabolic and physiological changes underlying frailty susceptibility in the elderly. While muscle-resident satellite cells are responsible f...
Difficulties and Challenges in Geriatric Health Management
Within modern medicine, a pressing concern looms; the care and well-being of our aging population. As the number of elderly individuals seeking medical attention continues to rise, healthcare professionals, particularly internists and family medicine specialists, find themselves faced with unique challenges in the diagnosis and management of geriatric patients. The specialized field of geriatrics demands a comprehensive understanding of the intricacies involved in providing top-tier care to the elderly. Without this expertise, there is a risk of suboptimal healthcare outcomes, diminished quality of life, and increased mortality rates. Difficulties and Challenges in Geriatric Health Managemen...
Human Aging
Human Aging: From Cellular Mechanisms to Therapeutic Strategies offers an exhaustive picture of all the biological aspects of human aging by describing the key mechanisms associated with human aging and covering events that could disrupt the normal course of aging. Each chapter includes a summary of the salient points covered, along with futures prospects. The book provides readers with the information they need to gain or deepen the skills needed to evaluate the mechanisms of aging and age-related diseases and to monitor the effectiveness of therapies aimed at slowing aging. The book encourages PhD and Postdoc students, researchers, health professionals and others interested in the biology of aging to explore the fascinating and challenging questions about why and how we age as well as what can and cannot be done about it. - Concentrates on different processes, e.g., oxidative stress, cellular senescence and Inflammaging - Offers the ability to access cross-sectional knowledge more easily - Written by expert researchers in biogerontology who are actively involved in various fields within aging research
Non avere paura di perderti
Circostanze inaspettate e coincidenze misteriose inducono la protagonista, una scrittrice decisa a ricominciare, a ripercorrere le orme di un onnipresente passato, costante ritorno e continuo divenire.
Atti parlamentari
Consists of separately numbered series of publications of the Parlamento as a whole, the Senato, and the Camera dei deputati. Each session is divided into Disegni di leggi; Documenti; and: Discussioni.
