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Pathobiology of the Human Atherosclerotic Plaque
Seymour Glagov The last meeting, devoted exclusively to an examination of the atherosclerotic plaque, took place in Chicago 25 years ago under the joint auspices of the Council on Arteriosclerosis of the American Heart Association and the Chicago Heart Association. The proceedings were published subsequently in a volume entitled "Evolution of the Atherosclerotic Plaque", edited by Richard J. Jones (1). Both experimental and human lesions were considered and several provocative new approaches to the disorder were discussed. The electron microscope was being applied systematically to the study of blood vessels at that time, so that details of the infrastructure and cellular composition of the artery wall and of atherosclerotic lesions were presented in some detail. There was, as one result of these explorations, considerable discussion of morphologic evidence suggesting that the principal cell involved in the atherogenic process was neither the fibroblast nor the macrophage, as had been supposed, but the smooth muscle cell. In particular, the findings indicated that this cell could incorporate lipid and become a foam cell.
Social System Accounts
Non-Invasive Imaging of Atherosclerosis is a primer, reference and review of some of the key features of current activities in the field of atherosclerosis. The Editors' goal is to provide material and stimulating ideas to basic scientists and clinical researchers in order to extend the application of vascular imaging and to further develop methods suitable for investigation of the arterial wall. The first section presents current knowledge about pathology, vascular mechanics and compensatory mechanisms active during atherogenesis. It explores the early lesion, complications of plaques and early detection of plaques. Section II reviews several key methodological issues of B-mode ultrasound i...
Broken Hearts
A history illustrating the complexity of medical decision making and risk. Still the leading cause of death worldwide, heart disease challenges researchers, clinicians, and patients alike. Each day, thousands of patients and their doctors make decisions about coronary angioplasty and bypass surgery. In Broken Hearts David S. Jones sheds light on the nature and quality of those decisions. He describes the debates over what causes heart attacks and the efforts to understand such unforeseen complications of cardiac surgery as depression, mental fog, and stroke. Why do doctors and patients overestimate the effectiveness and underestimate the dangers of medical interventions, especially when doing so may lead to the overuse of medical therapies? To answer this question, Jones explores the history of cardiology and cardiac surgery in the United States and probes the ambiguities and inconsistencies in medical decision making. Based on extensive reviews of medical literature and archives, this historical perspective on medical decision making and risk highlights personal, professional, and community outcomes.
CURRENT VASCULAR SURGERY
Current Vascular Surgery addresses contemporary topics and controversies in vascular and endovascular surgery, providing a comprehensive overview of the field’s recent evolution. The volume is the result of the 40th Annual Vascular Symposium sponsored by the Division of Vascular Surgery, Feinberg School of Medicine, Northwestern University. The symposium was held in Chicago on December 10–14, 2015. The symposium was held at the InterContinental Hotel on Chicago's Magnificent Mile. The symposium brought together over 50 national experts to address timely topics and controversies in vascular and endovascular surgery. As has been the tradition, presentations cover the full spectrum of vascular surgery including changes in management of extracranial cerebrovascular disease, new treatment options for lower extremity arterial occlusive disease, hemodialysis, improvements in techniques for complex venous disease, and developments in aortic stent graft repair in the chest and abdomen. Each chapter in this volume is based on a presentation, but the book chapters provide deeper, more detailed information than is possible in a symposium presentation.
Casebook of a Community Internist
Experience begets wisdom and wisdom informs change. “Patients are the best teachers,” he told a friend, shortly before moving west. The choice of a specialist career in community internal medicine came as a surprise to his colleagues. Leaving the big city hospital would mean less access to clinical resources, educational rounds, house staff, and practice support. In short, less “stuff .” Academia might have offered more. But Dr. Baillie moved to Mission, BC, not because he wanted less. He wanted to give rural Canadians more - the benefit of his extensive training - in their home town. Most of his time in Mission, BC, was in solo practice, working as internist and intensivist. Given h...
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