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The Alzheimer's Disease Challenge, Volume II
Given the success of Volume I of this Research Topic, we are pleased to announce the launch of Volume II: “The Alzheimer's Disease Challenge”. The repeated failure of clinical trials on the amyloid-based medications and the pessimistic calculations of Alzheimer's disease cost burden for the next few decades present a severe challenge to humankind with severe social implications. In recent years, several alternative diagnostic and treatment procedures have been presented to treat and manage Alzheimer’s disease as it has been nearly impossible to suggest a holistic solution. Several revelations in human biology have highlighted the multiparametric character of the disease. Besides the amyloid aggregation and neurofibrillary tangles that result in Aβ toxicity and tau phosphorylation, processes such as Gene Mutations, Proteins Misfolding, Brain Biochemical and Histopathological Changes, Behavioral Changes, Nutrition and Metabolism Alterations, and Autonomic Dysfunctions due to Central Nervous System dysregulations are common signs and probably early diagnostic biomarkers in most of the Alzheimer's classification categories.
Metal Nanocomposites in Nanotherapeutics for Oxidative Stress-Induced Metabolic Disorders
This book highlights the role and mechanism of different metal nanocomposites toward oxidative stress-induced metabolic disorders including metabolic pathways affected by oxidative stress and related pathophysiology. The book includes an illustrative discussion about the methods of synthesis, characterization, and biomedical applications of metal nanocomposites. It focuses on the therapeutic approaches for metabolic disorders due to oxidative stress by nano delivery systems. Moreover, the book includes chapters on nanotherapeutic approaches toward different diseases, including diabetes mellitus, obesity, cardiovascular disorders, cancers, and neurodegenerative diseases such as Alzheimer's di...
Plant-based Foods and their Implications in Brain Health
Phytoconstituents are a valuable source of new lead compounds due to their structural variety. The accelerated rate of human ageing brought about by the 21st century's longer life expectancy seems to be one of the major problems facing varied cultures worldwide. Ageing and the onset of chronic diseases appear to be significantly influenced by the type of food consumption pattern that people follow throughout their lives. There is strong evidence that Mediterranean diets are linked to a lower risk of brain disorders. A greater proportion of rural communities in the Mediterranean basin eat a diet high in plant-based foods daily. Stressors like reactive oxygen and reactive nitrogen species have...
Computational Approaches in Drug Discovery, Development and Systems Pharmacology
Computational Approaches in Drug Discovery, Development and Systems Pharmacology provides detailed information on the use of computers in advancing pharmacology. Drug discovery and development is an expensive and time-consuming practice, and computer-assisted drug design (CADD) approaches are increasing in popularity in the pharmaceutical industry to accelerate the process. With the help of CADD, scientists can focus on the most capable compounds so that they can minimize the synthetic and biological testing pains. This book examines success stories of CADD in drug discovery, drug development and role of CADD in system pharmacology, additionally including a focus on the role of artificial in...
Graphene-Based Nanomaterials
The book presents a comprehensive overview of the historical, current, and prospective application realms of nanobiotechnological research pertaining to graphene, a carbon-based nanomaterial, and its diverse forms in the fields of food and agriculture, as well as health sciences and technology. Young nanotechnologists and businesses will have access to nanobioanalytical methods. Given the present circumstances, it is crucial to underscore the potential ramifications that diverse forms of graphene nanomaterials could have on the food sector, agricultural methodologies, and healthcare. This book presents an analysis of the potential advantages of graphene-based nanomaterials over traditional m...
Bioprospecting of Tropical Medicinal Plants
This book focuses on natural products, in particular medicinal plants and their derived products, as an indispensable source of bioactive molecules that serve as either drug candidates or lead compounds for drug design and discovery . There are several advantages for plant-derived therapeutics, including wide availability, diverse pharmacological actions, and a generally good profile of safety and tolerability. Over the recent years, there have been numerous reports from clinical studies testifying the efficacy and safety of medicinal plants and phytochemicals in treating human diseases. A plethora of basic studies has also unraveled molecular mechanisms underlying the health benefits of her...
Breast Cancer Treatment
There are different types of treatment for breast cancer, including surgery, chemotherapy, radiotherapy, hormone therapy, immunotherapy, and targeted therapy. Deciding on the types of treatment depends on several factors, such as the stage and grade of cancer, biomarkers, and general health of patients. The seventh volume of the "Interdisciplinary Cancer Research" series, entitled "Breast Cancer Treatment: An Interdisciplinary Approach" publishes comprehensive reviews on different treatment opportunities on breast cancer. An update on treatment of triple-negative breast cancer and ductal carcinoma in situ is provided. Ablative breast cancer surgery, radiotherapy, and percutaneous breast canc...
Coldwater Fisheries and Aquaculture Management
This book is a rich resource of important information on coldwater fish farming and coldwater fisheries management, including new research and recent technological advances. It aims to provide an understanding of the underlying mechanisms of coldwater physiology of fishes, which is essential for effective fishery management and for taking advantage of their vast potential application in aquaculture. Coldwater Fisheries and Aquaculture Management: Technology for Sustainable Food Production elaborates on key aspects associated with reproductive biology and endocrinology of coldwater fishes, such as gonadal development and maturation, vitellogenesis, steroidogenesis, whole genome information of...
Papa's Coffee Machine
In Delhi's bustling streets, Mr. Zaidi embarks on a personal journey through virtual connections with his American-born grandchildren, Ayaan and Fazal. Amidst the aroma of kadak chai and freshly brewed coffee, Despite his reserved nature and seemingly dull existence, their conversations transcend time and distance, bringing unexpected warmth and joy. Delhi's charm and the warmth of coffee serve as the backdrop to their exchanges in this tale of intergenerational exploration. Hindered by language barriers, cultural differences, and Mr. Zaidi's reservations, their virtual encounters faltered. However, a longing for connection stirs within him, melting his apprehension away. Ayaan's coffee mug and lively spirit with the brewing curiosity of Fazal become catalysts for his own transformation. While Murad, a loving father, strives to foster a deeper bond between his sons and Mr. Zaidi. Follow Mr. Zaidi's heart, as the Zaidi family embarks on a journey of understanding and personal growth, filled with laughter, misunderstandings, and heartfelt conversations.
Phytonutrients in the Treatment of Gastrointestinal Cancer
Gastrointestinal cancer is one of the most prevalent causes of cancer-related deaths in the world. Recent research demonstrates that phytochemicals are critical in preventing and managing gastrointestinal cancer. The increased intake of phytochemicals could reduce the risk of cancer by inhibiting cancer cell proliferation, inducing apoptosis and autophagy, and suppressing angiogenesis as well as cancer cell metastasis. These mechanisms are also known to counter Helicobacter pylori infection and modulate gut microbiota. There is preliminary data suggesting that daily supplementation with high doses of certain vitamins combined with conventional therapeutic agents may enhance their growth inhi...
