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Reactive Oxygen Species in Biology and Human Health
Unlike other narrowly focused books, Reactive Oxygen Species in Biology and Human Health provides a comprehensive overview of ROS. It covers the current status of research and provides pointers to future research goals. Additionally, it authoritatively reviews the impact of reactive oxygen species with respect to various human diseases and discusses antioxidants and other compounds that counteract oxidative stress. Comprised of seven sections, the first section describes the introduction, detection, and production of ROS, emphasizing phenolic compounds and vitamin E for their abilities to act as antioxidants. This section also highlights the role of lipoprotein-associated oxidative stress. S...
Zulfikar Ali Bhutto
None
Molecular Mechanisms of Cockayne Syndrome
Cockayne syndrome (CS) is a rare autosomal genetic disorder that was first identified almost 62 years ago by Alfred Cockayne and was named after him. The earliest publication record (PubMed) available is a paper by Marie et al in 1958. Since then 815 research papers including excellent reviews have been published (PubMed, December 2008), yet we are
Molecular Mechanisms of Ataxia Telangiectasia
Ataxia telangiectasia (AT) is an incurable, rare autosomal recessive genetic disorder which affects approximately one in 40,000-100,000 and the carrier frequency is estimated to be 1:100-200. In the United Kingdom it affects 1 in 300,000 live births amounting to about 5 or 6 cases per year. Although the medial survival rate of affected persons is b
Diabetes
Diabetes: A Comprehensive Treatise for Patients and Care Givers is written with the intention of keeping readers abreast of the latest advancements, understanding, emerging trends, and technology in the field of diabetes. Several tables help to facilitate understanding of the concepts presented. Gestational diabetes, a topic commonly ignored, is also discussed in detail in a separate chapter. This book reviews recent findings of the most popular herbal medicines to treat diabetes through their relevant mechanism of actions. The book is unique in the sense that it is written for both care providers and patients. Chapter 18, Food and Diabetes; the Epilogue; and Appendices 1-4 are the sections especially designed and written for patients and care givers. An overview of above subjects will provide readers with a solid background to understand the exciting future developments in this rapidly moving science.
Diabetes
Diabetes is a complex disease and is also one of the most common. It is very difficult to reach an accurate estimate for the global prevalence of diabetes since the standards and methods of data collection vary widely in different parts of the world. In addition, many potential sufferers are not included in the count because according to an estimate about 50% of cases remain undiagnosed for up to 10 years. However, according to an estimate for 2010, globally, there are about 285 million people (amounting to 6.4% of the adult population) suffering from this disease. This number is estimated to increase to 439 million by 2030 if no cure is found. The general increase in life expectancy, leading to an ageing population, and the global rise in obesity are two main reasons for the increase. With the basic platform set, Editor presents his views and advice to the readers, especially to diabetic patients suffering from T2DM, on the basis of his observations and information collected from other diabetics.
Neurodegenerative Diseases
The editor of this volume, having research interests in the field of ROS production and the damage to cellular systems, has identified a number of enzymes showing ·OH scavenging activities details of which are anticipated to be published in the near future as confirmatory experiments are awaited. It is hoped that the information presented in this book on NDs will stimulate both expert and novice researchers in the field with excellent overviews of the current status of research and pointers to future research goals. Clinicians, nurses as well as families and caregivers should also benefit from the material presented in handling and treating their specialised cases. Also the insights gained should be valuable for further understanding of the diseases at molecular levels and should lead to development of new biomarkers, novel diagnostic tools and more effective therapeutic drugs to treat the clinical problems raised by these devastating diseases.
Aging
This book is a detailed and comprehensive synthesis of the scientific study of aging. Dozens of contributions from leading scholars review various theories of aging, and molecular, cellular, biochemical and microbial aspects of aging, among just a few of the topics included. Authoritative, wide ranging and thorough, this book will act as a source for experimental design, a comprehensive description of age related diseases, and provide information of the latest molecular theories underlying their causes. Additionally, it will target industries involved in developing anti-aging drugs, post-graduate medical students, and university libraries.
Handbook of Mitochondrial Dysfunction
Mitochondria produce the chemical energy necessary for eukaryotic cell functions; hence mitochondria are an essential component of health, playing roles in both disease and aging. More than 80 human diseases and syndromes are associated with mitochondrial dysfunction; this book focuses upon diseases linked to these ubiquitous organelles. Accumulation of mitochondrial DNA damage results in mitochondrial dysfunction through two main pathways. Mutation in mitochondrial DNA causes diseases such as Kearns-Sayre syndrome and Pearson syndrome. Mutation in chromosomal DNA causes diseases such as Parkinson's disease and schizophrenia. These and many other diseases are reviewed in this book. Key Features Presents the detailed structure of mitochondria, mitochondrial function, roles of oxidants and antioxidants in mitochondrial dysfunction. Includes summary of both causes and effects of these diseases. Discusses current and potential future therapies for mitochondrial dysfunction diseases Explores a wide variety of diseases caused by dysfunctional mitochondria.
